Journal
TETRAHEDRON LETTERS
Volume 50, Issue 30, Pages 4368-4371Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.053
Keywords
One-pot; Total synthesis; Natural product; THP; Centrolobine; Civet cat secretion
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Funding
- Nanyang Technological University
- Singapore Ministry of Education and Biomedical Research Council [05/1/22/19/408]
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A one-pot strategy is devised and applied to the total syntheses of natural products with a THP-ring backbone. A special feature of this one-pot synthesis is the recyclability of the indium complex byproduct generated from the indium-mediated allylation reaction for concurrent catalysis in subsequent steps. Centrolobine and civet cat secretion are synthesized via this new method in overall yields of 58% and 23%, respectively. (C) 2009 Published by Elsevier Ltd.
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