Journal
TETRAHEDRON LETTERS
Volume 50, Issue 30, Pages 4314-4317Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.026
Keywords
Multicomponent reactions; Isonitriles; Carboranes; Low-density lipoprotein; Boron neutron capture therapy
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Funding
- National Institutes of Health [CA129993]
- Whiteside Institute for Clinical Research
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Novel alpha-carboranyl-alpha-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents. (C) 2009 Elsevier Ltd. All rights reserved.
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