4.4 Article

Three-component Ugi-Smiles couplings of cyclic imines

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 15, Pages 1741-1743

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.01.145

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Cyclic imines react with isocyanides and electron-deficient phenols to afford N-aryl piperidines and pyrrolidines in good yields (Ugi-Smiles couplings of cyclic imines). The starting imines were formed by oxidation with N-chlorosuccinimide followed by a base-induced dehydrochlorination. (C) 2009 Elsevier Ltd. All rights reserved.

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