Journal
TETRAHEDRON LETTERS
Volume 50, Issue 23, Pages 2716-2718Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.085
Keywords
Diazo; N-H Insertion; Azacycle; Metathesis
Categories
Funding
- Office of Research and Sponsored Programs
- BioMolecular Innovation and Technology group (BMIT)
- Department of Chemistry and Biochemistry, Ohio University
Ask authors/readers for more resources
A series of five- to eight-membered nitrogen-containing heterocycles were prepared via a general and efficient one-pot, two-component sequence featuring rhodium-catalyzed insertion Of a vinyl-substituted alpha-diazocarbonyls into the N-H bond of a series of tert-butoxycarbonyl-(Boc)-protected amines, followed by ring-closing metathesis catalyzed by ruthenium benzylidene complexes, This methodology allows easy and convenient access to highly functionalized azacycloalkenes in moderate yields and excellent chemoselectivity in a single transformation. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available