Journal
TETRAHEDRON LETTERS
Volume 50, Issue 47, Pages 6526-6530Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.027
Keywords
DNA cleavage; Lysine; 1.3 Dipolar cycloaddition reaction; Fullerene
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
- UGC, New Delhi
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A novel water-soluble [60] fullerene-substituted lysine derivative 3 has been synthesized and characterized by elemental analysis. H-1 NMR. C-13 NMR and FAB-MS The synthetic procedure involved condensation of Boc-protected lysine with terephthaldehyde followed by 1,3-dipolar cycloaddition reaction with C-60 in the presence of sarcosine and finally deprotection of the amino group using trifluoroacetic acid. The synthesized compound 3 exhibited high DNA cleavage efficiency upon visible light irradiation in the presence of NADH (C) 2009 Elsevier Ltd. All rights reserved.
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