Journal
TETRAHEDRON LETTERS
Volume 50, Issue 19, Pages 2236-2238Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.186
Keywords
Macrocycles; Foldamers; Supramolecular chemistry; Protecting groups
Categories
Funding
- University of Leeds
- Engineering and Physical Sciences Research Council [EP/D077842/1]
- EPSRC [EP/D077842/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D077842/1] Funding Source: researchfish
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A p-benzenetricarboxamide macrocycle linked through secondary cis amides is obtained via cyclisation and subsequent deprotection of a folded linear precursor. Secondary benzamides strongly prefer the trans conformation, therefore this synthesis can be considered 'impossible' without recourse to protecting groups. (C) 2009 Elsevier Ltd. All rights reserved.
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