Journal
TETRAHEDRON LETTERS
Volume 49, Issue 7, Pages 1199-1202Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.12.030
Keywords
one-pot; reductive monoalkylation; nitro aryls; secondary alkyl amino aryls; Pd/C
Categories
Ask authors/readers for more resources
A range of different nitro aryls were converted in one-pot to the corresponding secondary alkyl amino aryls in good to excellent yields by using aldehydes as alkyl source and hydrogen over Pd/C (10%) as reducing agent. In all examples, but one, the secondary amine was the sole alkylation product isolated. When formaldehyde was used as the alkyl source, substantial amount of the corresponding tertiary amine was isolated, however, by altering the reaction conditions slightly the corresponding secondary amine could be isolated in superb yield. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available