4.4 Article

IBX/I2-mediated oxidation of alkenes and alkynes in water:: a facile synthesis of α-iodoketones

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 41, Pages 5880-5882

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.07.120

Keywords

aromatic alkynes; alkenes; hypervalent iodine; alpha-lodoketones

Funding

  1. CSIR, New Delhi

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The conversion of alkenes into alpha-iodoketones has been achieved in good yields and with high regioseiectivity by means of iodohydrin formation and subsequent oxidation with 2-iodoxybenzoic acid (IBX) under mild conditions. Aromatic alkynes are also converted into their corresponding alpha-iodoketones Under similar conditions. (C) 2008 Elsevier Ltd. All rights reserved.

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