Journal
TETRAHEDRON LETTERS
Volume 49, Issue 25, Pages 4026-4028Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.04.082
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In this Letter, we describe a practical, green iodination of pyrazoles to form the corresponding 4-iodopyrazole derivatives. The reaction takes place in water, using only 0.5 equiv of iodine and 0.6 equiv of hydrogen peroxide, a system that generates water as the only reaction by-product. (C) 2008 Elsevier Ltd. All rights reserved.
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