4.4 Article

Convenient synthesis of 1,1′-H-spiro[indoline-3,3′-piperidine]

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 28, Pages 4372-4373

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.05.024

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The spirocyclic indoline ring system represents an important scaffold for the discovery of novel therapeutics. Herein, we describe the synthesis of 1,1'-H-spiro[indoline-3,3'-piperidine] using an intramolecular palladium-catalyzed alpha-arylation reaction. (C) 2008 Elsevier Ltd. All rights reserved.

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