4.4 Article

Catalytic asymmetric diethylzinc addition to diphenylphosphionyl imines using chiral tert-butanesulfinylphosphine ligands

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 48, Pages 6921-6923

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.111

Keywords

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Funding

  1. National Natural Science Foundation of China [20872139]
  2. National Engineering Research Center of Chiral Drugs

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A class of novel chiral tert-butanesulfinylphosphine ligands were designed and synthesized by a concise two-step route with high yields. High activities and enantioselectivities (up to 94% ee) were achieved when using them in catalytic asymmetric diethylzinc addition to diphenylphosphinoyl imines. (C) 2008 Elsevier Ltd. All rights reserved.

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