Journal
TETRAHEDRON LETTERS
Volume 49, Issue 51, Pages 7290-7293Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.035
Keywords
Asymmetric catalysis; Hydrogenation; Enamines; Chiral tertiary amines
Categories
Funding
- The Swedish Research Council [2006-3611]
- ERASMUS-Programme
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The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee. (C) 2008 Elsevier Ltd. All rights reserved.
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