Journal
TETRAHEDRON LETTERS
Volume 49, Issue 49, Pages 7037-7041Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.145
Keywords
Enamine catalysis; Primary amine; Aldol reaction; Polysiloxane; Organocatalysis
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Funding
- Hangzhou Normal University
- National Nature Science Foundation of China [20572114]
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We have developed a new strategy to improve the stereoselectivity in enamine catalysis by the introduction of super-hydrophobic long-chain silicone/polysiloxane as support/functional group for a model aldol reaction. The homogeneous direct aldol reaction of cyclic ketones with different aromatic aldehydes catalyzed by polysiloxane-derived primary amines has been reported with high yields, good diastereoselectivity, and Lip to 99% ee. (c) 2008 Elsevier Ltd. All rights reserved.
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