Journal
TETRAHEDRON LETTERS
Volume 49, Issue 47, Pages 6610-6612Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.018
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Funding
- National Institutes of Health [HL25848, CA103823]
- Guthikonda Fellowship
- Bristol-Myers Squibb Graduate Fellowship
- Sylvia & Victor Fourman Fellowship
- National Science Foundation [CHE-0619638]
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We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to the development of a SAR program based on diverted total synthesis. (C) 2008 Elsevier Ltd. All rights reserved.
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