4.4 Article

Indium-HI-mediated one-pot reaction of 1-(2-arylethynyl)-2-nitroarenes to 2-arylindoles

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 23, Pages 3733-3738

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.04.032

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While 1-(2-arylethynyl)-2-nitroarenes were reduced to 2-(2-arylethynyl)anilines in the presence of indium and InCl3 in THF/H2O (v/v = 5/1) at 50 degrees C, 1-(2-arylethynyl)-2-nitroarenes were reductively cyclized to 2-arylindoles with good yields in the presence of indium and aqueous HI in benzene. (C) 2008 Elsevier Ltd. All rights reserved.

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