4.4 Article

Convenient synthesis of chiral non-racemic S-mesityl sulfinimines

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 7, Pages 1129-1132

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.12.067

Keywords

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Funding

  1. EPSRC [EP/E055346/2] Funding Source: UKRI
  2. Engineering and Physical Sciences Research Council [EP/E055346/2] Funding Source: researchfish

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A direct multi-component coupling of (2S,4R,5S)-N-tosyl-4-methyl-5-phenyl-1,2,3-oxathiozolidine-2-oxide with mesityl magnesium bromide, LHMDS and a range of aldehydes produces chiral sulfinimines in essentially optically pure form in an operationally simple single pot procedure. (C) 2008 Elsevier Ltd. All rights reserved.

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