4.4 Article

Synthesis of 1H-isochromen-1-ylphosphonates via AgOTf-catalyzed reaction of 2-alkynylbenzaldehyde with diethyl phosphite

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 28, Pages 4390-4393

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.05.009

Keywords

2-alkynylbenzaldehyde; diethyl phosphate; 1H-isochromen-1-ylphosphonate; silver triflate

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Tandem cyclization-addition reaction of 2-alkynylbenzaldehyde with diethyl phosphite catalyzed by AgOTf at room temperature was developed, which afforded the desired 1H-isochromen-1-ylphosphonates in moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.

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