Journal
TETRAHEDRON LETTERS
Volume 49, Issue 51, Pages 7318-7321Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.046
Keywords
Groebke-Blackburn multi-component reaction; Convertible isocyanide; tert-Butyl isocyanide; Combinatorial chemistry
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tert-Butyl isocyanide can serve as the convertible reagent in Groebke-Blackburn multi-component reactions. The effective removal of the tert-butyl group from the resulting imidazo[1,2-a]azines and -azoles is achieved on a gram scale in two steps without chromatographic purification. (C) 2008 Elsevier Ltd. All rights reserved.
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