Journal
TETRAHEDRON LETTERS
Volume 49, Issue 34, Pages 5077-5079Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.06.035
Keywords
phomallenic acid C; inhibitor of FAS II pathway; anti-S(N)2' coupling; Ohrui-Akasaka method
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Enantioselective synthesis of phomallenic acid C, an inhibitor of bacterial FAS II pathway, was successful. Allenyldiyne structure was constructed by a direct anti-S(N)2' coupling of propargyl mesylate with diyny-lindium in the presence of palladium catalyst. Enantiomeric purity was determined by Ohrui-Akasaka method to be 83%ee. (c) 2008 Elsevier Ltd. All Fights reserved.
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