Journal
TETRAHEDRON
Volume 70, Issue 30, Pages 4494-4499Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.05.006
Keywords
Illicium jiadifengpi; Stems; Diterpenes; Sesquiterpenes; Anti-Coxsackie virus B3
Categories
Funding
- Natural Science Foundation of China [201072234, 21132009]
- National Science and Technology Project of China [2012ZX09301002-002]
- PCSIRT [IRT1007]
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Seven new diterpenes, jiadifenoic acids J-P (1-7), two new sesquicarane sesquiterpenes, sesquicaranoic acids A and B (8 and 9), and four known compounds, were isolated from the stems of Illicium jiadifengpi. The trans-fused A/B ring junction in diterpenes was deduced from NMR data analysis and confirmed by single-crystal X-ray crystallography of 3. The absolute configurations of compounds 1 and 5 were determined using the Mo-2(OAc)(4)-induced circular dichroism (ICD) method. Compounds 8 and 9 are a pair of C-10 epimers, and their absolute configurations were confirmed by analyzing their CD and ICD data. All of the isolated compounds were evaluated in vitro for their antiviral activities against Coxsackie virus B3 (CVB3). Among the isolated compounds, 4, 5, 7, 10, and 11 exhibited reasonable activity against CVB3, with IC50 values of 7.0-22.2 mu mol/mL and selective index values (SI=TC50/IC50) of 49.3, 37.1, 31.3, 45.6 and 40.9, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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