4.4 Article

Electronic tuning cyclization of aryl-1,4-enediones: AlCl3-mediated Nazarov-type cyclization to synthesize polysubstituted-1-indanones

Journal

TETRAHEDRON
Volume 70, Issue 50, Pages 9536-9544

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.10.052

Keywords

Nazarov cyclization; 1,4-Enediones; AlCl3; Polysubstituted-1-indanones

Funding

  1. National Natural Science Foundation of China [21032001, 21272085]

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An electronic tuning Nazarov-type cyclization protocol was proposed for the synthesis of polysubstituted-1-indanones from the readily available starting materials 1,4-enediones. AlCl3 was highlighted as the most efficient promoter for this reaction. (C) 2014 Elsevier Ltd. All rights reserved.

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