T3P®-assisted esterification and amidation of phosphinic acids

A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P (R)). If 1.1 equiv of the T3P (R) reagent is used, the esterifications are fast and efficient at 25 degrees C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P (R) at 85 degrees C under microwave conditions. The amidation of 1-hydroxy-3-methyl-3-phospholene oxide could also be accomplished under similar conditions. (C) 2014 Elsevier Ltd. All rights reserved.