Journal
TETRAHEDRON
Volume 70, Issue 43, Pages 8017-8022Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.08.042
Keywords
Huperziaceae; Huperzia carinata; Huperzia squarrosa; Lycopodium alkaloid; Acetylcholine esterase
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Funding
- Thailand Research Fund [BRU5680005]
- Royal Project Foundation [3040 A013]
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Eleven Lycopodium alkaloids with lycodine-type, lycopodine-type, and fawcettimine-related skeletons were isolated from the whole plants of Huperzia carinata (Desv. Ex. Poir.) Trevis and Huperzia squarrosa (G. Forst) Trevis (Huperziaceae). Among them, 8,15-dihydrohuperzine A (2), lycocarinatine A (3), and lycoposerramine U N-oxide (11) are new compounds. The structures of these new alkaloids were elucidated on the basis of 2D NMR correlations. Some of these isolated alkaloids were assayed for acetylcholinesterase (AChE) inhibitory activity. (C) 2014 Elsevier Ltd. All rights reserved.
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