Iodine-mediated electrophilic tandem cyclization of 2-alkynylbenzaldehydes with anthranilic acid leading to 1,2-dihydroisoquinoline-fused benzoxazinones

An efficient iodine-mediated electrophilic tandem cyclization of substituted 2-alkynylbenzaldehydes with anthranilic acids under basic medium leading to iodo-1,2-dihydroisoquinoline-fused benzoxazinones is presented. Success of the protocol for the reaction of substituted 2-alkynylbenzaldehydes with 2-aminobenzamides to furnish isoquinoline-fused quinazolinones is also described. (C) 2013 Elsevier Ltd. All rights reserved.