Article
Chemistry, Physical
K. Ramki, R. Selva Kumar, G. Thiruppathi, P. Sundararaj, P. Sakthivel
Summary: A new ratiometric fluorescent sensor for mercury detection was developed using heterocyclic Schiff's bases. The sensor showed strong fluorescence with a large Stoke shift, but upon interaction with Hg(II), the fluorescence was enhanced and blue shifted. The sensor exhibited high sensitivity and selectivity towards Hg(II) in water samples and Caenorhabditis elegans.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Biochemical Research Methods
Mahantesh Budri, Kalagouda B. Gudasi, Ramesh S. Vadavi, Satish S. Bhat
Summary: In this study, a novel photoluminescent sensor based on a pyrene platform was developed, showing high selectivity and sensitivity towards Hg2+. The detection limit and association constant of the sensor for mercury were calculated using experimental results and fluorescence titration data. The practical application of the sensor for recognition of mercury(II) ions was successfully explored through economically viable test strips and cell imaging studies.
JOURNAL OF FLUORESCENCE
(2023)
Review
Engineering, Biomedical
Shanshan Jiang, Jing Lin, Peng Huang
Summary: This review summarizes the recent advances in nanomaterials for photoacoustic imaging (PAI) in the second near-infrared window (NIR-II) and discusses the advantages of NIR-II PAI and its applications in the biomedical field. The nanomaterials-based PA contrast agents are categorized into organic, inorganic, and organic/inorganic hybrid nanomaterials, which are mainly used for imaging and diagnosis of tumor tissues, brain vasculature, inflammation, and other tissues, as well as for monitoring catalytic reaction processes in vivo. The opportunities and challenges of NIR-II PAI are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mengyao Zhao, Jianbo Wang, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, Fan Zhang
Summary: The newly developed pTAS sensors can achieve high sensitivity tumor pH monitoring within a wider response region, extending the pH detection range. Through dual-channel ratiometric bioimaging, the dynamic changes in tumor pH can be visualized in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Hong-Mei Zhao, Tao Sun, Jiang Wang, Ai-Ju Xu, Mei-Lin Jia, Bin Xue
Summary: A novel phosphorus-doped carbon nitride oligomer-based fluorescence sensor with needle-like nanostructures and terminal amino and hydroxyl functional groups was synthesized via hydrothermal reaction, showing selective quenching towards mercury (II) ions. The sensor achieved a minimum detection limit of 0.35 nmol L-1 in the range of 1-100 nmol L-1 and demonstrated sensitivity and accuracy in detecting mercury (II) ions in actual shrimp samples.
Review
Chemistry, Multidisciplinary
Janasik Dawid, Tomasz Krawczyk
Summary: This review discusses the application of multimodal F-19 MRI probes in combination with various imaging techniques, highlighting their ability to compensate for the limitations of individual techniques and improve detection sensitivity and accuracy. Strategies for designing F-19 MRI multimodal probes are also described.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Dawid Janasik, Tomasz Krawczyk
Summary: This review discusses the development of F-19 MRI multimodal probes in combination with various imaging techniques, highlighting how they compensate for deficiencies in individual techniques and improve sensitivity and accuracy of detection. Strategies for designing these probes focus on structure, physicochemical properties, biocompatibility, and image quality.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Hongbao Fang, Yaheng Li, Xiuzhi Yang, Yuncong Chen, Zijian Guo, Weijiang He
Summary: This review summarizes the design and application of fluorescent probes for zinc ion (Zn2+) imaging in organelles, cells, and live organisms reported in the past two years. The goal is to provide inspiration for the design of new Zn2+ probes for multi-level monitoring and deepen the understanding of Zn2+ biology.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Analytical
Victoria Ivanova, Darya Klyamer, Pavel Krasnov, Esra Nur Kaya, Irem Kulu, Sinem Tuncel Kostakoglu, Mahmut Durmus, Tamara Basova
Summary: This study investigates the impact of the number of pyrene substituents on the sensor properties of hybrid materials consisting of zinc(II) phthalocyanine molecules and single-walled carbon nanotubes (SWCNT). Five different trioxyethylenethio substituted zinc(II) phthalocyanines, varying in the number of methoxypyrene substituents in the phthalocyanine ring, were prepared and characterized. The hybrids with four methoxypyrene substituents exhibited the highest sensor response to ammonia among the prepared materials.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Acoustics
Ayoung Choe, David Qin, Anthony M. Yu, Euisuk Chung, Anamik Jhunjhunwala, Julian A. Rose, Stanislav Y. Emelianov
Summary: The cancer microenvironment has a lower pH than healthy tissues, which can be exploited for more accurate cancer biopsy. A needle coated with pH-responsive PANI nanoparticles is developed for minimally invasive and quantitative pH analysis using ratiometric PA imaging. The PANI-needle shows a linear response in the 850-700 nm wavelength range as pH changes from 7.5 to 6.5. Its high surface area allows for fast and reversible response in just a few seconds. The PANI-needle successfully differentiates local pH in a hydrogel phantom with different pH regions, making it a promising technology for malignant tissue detection during needle biopsy through quantitative pH analysis guided by ultrasound PA imaging.
Article
Multidisciplinary Sciences
Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong, Wen Li, Ji Qi
Summary: Researchers have developed a polymer nanoplatform for thrombus imaging and treatment in the near-infrared-II region, offering a versatile approach for the diagnosis and treatment of life-threatening diseases caused by thrombotic disorders.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Dong-Hao Li, Rananjaya S. Gamage, Allen G. Oliver, Nimit L. Patel, Syed Muhammad Usama, Joseph D. Kalen, Martin J. Schnermann, Bradley D. Smith
Summary: This study reports a synthetic method for producing novel doubly strapped zwitterionic heptamethine cyanine dyes with enhanced stability. These dyes, including a structural analogue of ZW800-1, can be conjugated to proteins, including monoclonal antibodies, without causing fluorophore degradation or dye stacking. The fluorescent antibody conjugates show excellent tumor-targeting specificity in a xenograft mouse tumor model. The enhanced stability provided by the doubly strapped molecular design enables new classes of in vivo NIR fluorescence imaging experiments with possible translation to humans.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Environmental Sciences
Xiang Cheng, Ting Luo, Feiyi Chu, Bin Feng, Shibo Zhong, Fei Chen, Jie Dong, Wenbin Zeng
Summary: This review summarizes the recent advances in multifunctional materials for detection, detoxification, adsorption, and removal of mercury ions, discusses the advantages and disadvantages of different types of sensors, and points out the future development direction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Chemistry, Multidisciplinary
Reza Tabaraki, Farzaneh Hajisharifi
Summary: In this study, carbon dots doped with nitrogen and sulfur were synthesized using microwave from two initial precursors. The choice of doping agent influenced the surface functional groups, morphology, and optical properties of the carbon dots. The synthesized N, S co-doped carbon dots were used as a fluorescent probe for titanium and exhibited fast response time and good sensitivity and selectivity. Additionally, nitrogen-doped carbon dots synthesized from acetamide were used as a fluorescent probe for Hg2+ and showed excellent performance.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
