Journal
TETRAHEDRON
Volume 69, Issue 32, Pages 6687-6692Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.05.115
Keywords
Salvia przewalskii; Abietane diterpenoids; Circular dichroism; Antibacterial activity
Categories
Funding
- National Natural Science Foundation of China [21202075, 21272103]
- 111 Project
- Scientific Research Foundation For Returned Overseas Students [45]
- Scientific Research Ability Training of undergraduate students majoring in chemistry by the two patters based on the tutorial system and top students project [J1103307]
- Fundamental Research Funds for the Central Universities [LZUJBKY-2011-75]
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In an antibiotic screening program for new drug leads, we discovered a seco-norabietane diterpenoid with an unprecedented carbon skeleton, salprzelactone (1), together with three new abietanoids (2-4) from the roots of Salvia przewalskii. Their structures were mainly elucidated by NMR and MS data. The structures of 1 and 4 were elucidated by comprehensive spectroscopic and a single-crystal X-ray crystallographic analysis with the absolute configuration determined by the CD approach coupled with theoretical CD spectra. Those compounds were evaluated for their antibacterial activities against six bacteria. (C) 2013 Elsevier Ltd. All rights reserved.
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