Journal
TETRAHEDRON
Volume 69, Issue 51, Pages 10811-10819Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.10.093
Keywords
Aldol reaction; Organocataiysis; Prolinamides; Supported catalysts; Supported prolinamides
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Funding
- Spanish DGICYT [CTQ 2011-28487]
- Universidad of Valladolid
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Five novel prolinamides derived from 1,n-diamines supported on commercially available sulfonylpolystyrene have been synthesized and successfully applied in diastereo- and enantioselective aldol reaction in water or, in one case, neat conditions. Excellent dr and er were obtained by reaction of different cyclohexanone derivatives with aromatic and heteroaromatic aldehydes in the presence of the catalysts and AcOH as co-catalyst. The supported organocatalysts work in low loading (5 mol %) exhibiting similar performances than homogeneous prolinamides, and can be reused, after activation, without loss of activity. (C) 2013 Elsevier Ltd. All rights reserved.
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