Journal
TETRAHEDRON
Volume 68, Issue 3, Pages 813-818Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.032
Keywords
Tryptamine derivatives; One-pot process; Multi-component reaction; Fischer indole type pathway
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We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. Published by Elsevier Ltd.
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