Article
Engineering, Marine
Obai Kargbo, Mi-An Xue, Jinhai Zheng, Xiaoli Yuan
Summary: This study utilized a numerical model to simulate the interaction between stratified layers of liquid oil and water in a rectangular tank with a T-shaped baffle, analyzing the impact of a porous structure on sloshing waves and tank wall pressure.
Article
Mechanics
Vladimir Chirkov, Ioann Dobrovolskii, Sergei Vasilkov
Summary: This paper investigates the electrical deformation of conducting droplets in two-phase immiscible liquids and the EHD conduction pumping phenomenon. The study shows that when one of the liquids is a low-conducting medium, this conduction pumping occurs near the interface of the two immiscible liquids. The space charge influences the Coulomb force, affecting the droplet electrodeformation.
Article
Biochemistry & Molecular Biology
Dahbia Yatoui, Philipp O. Tsvetkov, Romain La Rocca, Viktoriia E. Baksheeva, Diane Allegro, Gilles Breuzard, Geraldine Ferracci, Deborah Byrne, Francois Devred
Summary: Researchers have identified three zinc binding sites on Tau protein and found that zinc binding to these sites plays an important role in aggregation. Particularly, lack of zinc binding to the high affinity site in the repeat region prevents Tau protein from aggregating.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Alicio Wagner Vieira, Keycianne da Cruz Silva, Aparecida Barbosa Mageste, Guilherme Dias Rodrigues, Leandro Rodrigues de Lemos
Summary: This study characterized new ATPS formed by PVP10K with different salts and water, with findings showing that temperature and pH had minimal influence on the phase region, sodium sulfate was more efficient than zinc sulfate, and the partition of lycopene in ATPS was driven enthalpically.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Mechanical
Shaodi Zhao, Jiusheng Bao, Shirong Ge, Zhongbin Wang, Yan Yin, Yuefeng Li
Summary: Elbow wear poses a significant threat to the multiphase pipeline transportation industry. Placing a swirler upstream of elbows can reduce wear. Using the dense discrete phase model (DDPM), the effects of different concentrations, particle sizes, and flow velocities on elbow wear with and without the swirler were studied, revealing the formation mechanism of different wear morphologies. Mathematical models were established to relate conveying parameters to the maximum wear rate (MWR), and the conveying parameters most suitable for reducing elbow wear using the swirler were determined. Bench tests showed that the MWR of horizontal-horizontal (H-H), horizontal-vertical (H-V), and vertical-horizontal (V-H) elbows could be reduced by 51.9%, 35.5%, and 23.2% respectively.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Wenlong Wang, Rogelio Diaz-Mendez, Mats Wallin, Jack Lidmar, Egor Babaev
Summary: This study numerically investigates nonequilibrium glass formation and depinning transition in a system of two-dimensional cluster-forming monodisperse particles with pinning disorder. The results show that vortex interaction is the dominant factor in cluster glass formation, while pinning can significantly affect glass formation. Vortices with cluster-forming interaction forces exhibit stronger pinning effects compared to regular vortices.
Article
Nanoscience & Nanotechnology
Yuhan Sun, Minghui Li, Xiaolei Qu, Shourong Zheng, Pedro J. J. Alvarez, Heyun Fu
Summary: The Pt/CNT@CN catalyst showed higher initial activity and better stability compared to commercial Pt/C and uncoated Pt/CNT, making it an effective approach for removing Se(IV) in water.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Xiaoxing Lu, Zhizhuo Lu, Rong Zhang, Lijiang Zhao, Hujun Xie
Summary: This study investigates the phase behaviors and pigment extraction performance of ionic liquid-based aqueous two-phase systems formed by piperazinium ILs and anionic surfactants, showing a preference for curcumin separation. Factors influencing extraction efficiency and distribution coefficients, as well as the separation mechanism, were evaluated.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Physics, Multidisciplinary
L. N. Carenza, G. Gonnella, D. Marenduzzo, G. Negro, E. Orlandini
Summary: This study investigates the phase behavior of quasi-two-dimensional cholesteric liquid crystal shells and discovers novel topological phases that differ from those observed on flat geometries. For spherical shells, finite quasicrystals and amorphous structures are identified, which are made up of mixtures of polygonal tessellations of half-skynnions. For toroidal shells, variations in local curvature lead to the stabilization of heterogeneous phases where cholesteric patterns coexist with hexagonal lattices of half-skyrmions. These findings provide important insights for experimental self-assembling of cholesteric shells.
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Physical
Abdus Salam Sarkar, Emmanuel Stratakis
Summary: The exfoliation and dispersion behavior of Germanium (II) monosulfide (GeS) and Tin (II) monosulfide (SnS) nanosheets in various organic solvents were investigated, resulting in significant yields of isolated GeS and SnS flakes in 2-propanol and N-Methyl-2-pyrrolidone. The isolated flakes are few-layer nanosheets suitable for scalable solution processable printed electronic device applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Chinmayee Chowde Gowda, Raphael Tromer, Prafull Pandey, Dharita Chandravanshi, Amreesh Chandra, Kamanio Chattopadhyay, Douglas S. Galvao, Chandra Sekhar Tiwary
Summary: We successfully synthesized two-dimensional manganese telluride (MnTe) using a scalable synthesis method and observed a transition from antiferromagnetic to paramagnetic behavior. Enhanced magnetic saturation values (up to 400% increase) were observed compared to bulk MnTe at room temperature. Density functional theory simulations explain the layer-dependent magnetic behavior of the 2D MnTe flakes and the antiferromagnetic to paramagnetic transition due to an unbalanced spin population.
Article
Nanoscience & Nanotechnology
Quanyong Cheng, Jingyi Chen, Chuchu Wan, Yuhang Song, Caili Huang
Summary: This study reports a facile route to prepare Janus droplets and hydrogels via aqueous two-phase systems (ATPS). The Janus droplets with different morphologies can be well controlled by manipulating the concentrations of polymers on the phase diagram. The introduction of monomers and/or nanoparticles in ATPS droplets followed by photopolymerization enables the synthesis of Janus hydrogel particles with diverse functionalities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Henry David Jetmore, Edappalil Satheesan Anupriya, Tanner Joe Cress, Mei Shen
Summary: The interface between two immiscible electrolyte solutions (ITIES) is important in various fields and allows for the detection of complex molecules that are less suited to probing by solid electrodes.
ANALYTICAL CHEMISTRY
(2022)
Article
Acoustics
Kevin Synnatschke, Narine Moses Badlyan, Angelika Wrzesi, Guillermo Lozano Onrubia, Anna -Lena Hansen, Stefan Wolff, Hans Tornatzky, Wolfgang Bensch, Yana Vaynzof, Janina Maultzsch, Claudia Backes
Summary: Liquid phase exfoliation (LPE) has been used to successfully fabricate nanosheets from various van der Waals materials. However, it also alters the chemistry of the materials due to increased effective surface area, resulting in enhanced reactivity and accelerated oxidation. To overcome material decomposition, LPE and processing in an inert atmosphere have been developed. In this study, the inert exfoliation of the oxidation-sensitive van der Waals crystal, CrTe3, was demonstrated.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Physical
Tianyi Hang, Jiajia Zheng, Yijie Zou, Shaohua Jiang, Yuchen Zhao, Zhaochun Li, Lijie Zhou, Xiping Li, Guoxiu Tong, Yiming Chen
Summary: A multi-scale composite elastomer with ecoflex/2D MXene@zero-dimensional CoNi sphere@one-dimensional carbon nanotube was successfully synthesized. The binding between the fillers and matrix enhanced the electromagnetic wave absorption capability and mechanical properties. The composite exhibited an excellent minimum reflection loss of -67 dB at 9.46 GHz and an ultrabroad effective absorption bandwidth of 6.07 GHz.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Francesca Annunziata, Alessandra Guaglio, Paola Conti, Lucia Tamborini, Raffaella Gandolfi
Summary: Immobilized whole cells of Rhodotorula rubra MIM147 were used in a packed bed flow reactor for enantioselective reduction of beta-ketonitriles and efficient production of a key building block for the synthesis of the antidepressant drug duloxetine. A choline chloride-glucose natural deep eutectic solvent (NADES) was employed as a co-solvent and glucose source for cofactor regeneration, with an in-line purification procedure developed. The optimized protocol allowed the obtainment of (S)-beta-hydroxynitriles with >95% conversion and excellent enantiomeric excess in 80 minutes of residence time.
Article
Polymer Science
Cesare Rovera, Simone Luti, Luigia Pazzagli, Ellen L. Heeley, Chaoying Wan, Diego Romano, Stefano Farris
Summary: The study investigated the effect of expansin-like cerato-platanin protein as a pre-treatment for enzymatic hydrolysis of bacterial cellulose. Higher concentrations of the protein hindered the hydrolysis process, leading to lower content of cellobiose and glucose. This anomalous behavior of cerato platanin family members contrasts with their positive effects on plant-derived cellulose.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Immacolata Serra, Lorena Wilson, Andres R. Alcantara
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Andres R. Alcantara, Pablo Dominguez de Maria, Jennifer A. Littlechild, Martin Schurmann, Roger A. Sheldon, Roland Wohlgemuth
Summary: In this article, the authors discuss the importance of biocatalysis in sustainable industrial chemistry and provide insights into future prospects for the field.
Article
Chemistry, Multidisciplinary
Andres R. Alcantara, Pablo Dominguez de Maria, Jennifer A. Littlechild, Martin Schurmann, Roger A. Sheldon, Roland Wohlgemuth
Summary: The role and power of biocatalysis in sustainable chemistry have been brought to the forefront through significant achievements in biology, chemistry, and engineering. Biocatalytic synthesis is now widely applied in modern chemistry, accelerating the implementation of sustainable chemistry. It has provided numerous benefits to various industries and has the potential to contribute to the design of new value-creation chains.
Article
Chemistry, Physical
Raffaella Gandolfi, Giorgio Facchetti, Lucia Cavalca, Stefania Mazzini, Milena Colombo, Giulia Coffetti, Gigliola Borgonovo, Leonardo Scaglioni, Sarah Zecchin, Isabella Rimoldi
Summary: The recycling of heavy metal contaminants from wastewater as a source of valuable products perfectly fits with the principles of a Circular Economy system. Biosorption using EPSs produced by bacterial cells is a sustainable and efficient method for removing metal cations from wastewater. Different strains of bacteria were tested for their ability to sequester copper, and the copper chelates obtained were successfully used as catalysts in the synthesis of pharmaceutical intermediates.
Review
Pharmacology & Pharmacy
Gonzalo de Gonzalo, Andres R. Alcantara, Pablo Dominguez de Maria, Jose Maria Sanchez-Montero
Summary: The use of biocatalysis in the synthesis of active pharmaceutical ingredients (APIs) is a powerful strategy, enabled by advancements in molecular biology techniques. This paper presents examples of various enzymes, including lipases, oxidoreductases, and transaminases, that can be integrated into complex pharmaceutical multi-step syntheses. The examples demonstrate high substrate loadings and excellent selectivity, making them promising for industrial applications.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Article
Chemistry, Applied
Francesca Annunziata, Martina L. Contente, Valentina Anzi, Silvia Donzella, Paola Conti, Francesco Molinari, Piera Anna Martino, Gabriele Meroni, Valerio Massimo Sora, Lucia Tamborini, Andrea Pinto
Summary: This study synthesized a collection of nature-inspired lipophilic phenolic esters using immobilized lipase in cyclopentyl methyl ether. The obtained compounds showed enhanced lipophilicity compared to the parent non-esterified compounds, making them potential additives in the food industry.
Article
Chemistry, Medicinal
Inmaculada Aranaz, Niuris Acosta, Julia Revuelta, Agatha Bastida, Victor Gomez-Casado, Concepcion Civera, Leoncio Garrido, Eduardo Garcia-Junceda, Angeles Heras, Andres R. Alcantara, Alfonso Fernandez-Mayoralas, Ernesto Doncel-Perez
Summary: Brain-derived neurotrophic factor (BDNF) plays a regulatory role in dendritic branching, dendritic spine morphology, synaptic plasticity, and long-term potentiation. Its deficiency is associated with neurodegenerative diseases, while elevated levels are linked to recovery after CNS injuries. To overcome the limitations of BDNF as a therapeutic agent, we tested the efficacy of chitosan microsphere-encapsulated BDNF. Our results demonstrate that slow release of BDNF from chitosan microspheres enhances neuritic growth and axonal growth, making it a potential therapeutic agent for neurodegenerative diseases and CNS lesions.
Article
Chemistry, Physical
Thays N. da Rocha, Roberto Morellon-Sterling, Luciana R. B. Goncalves, Juan M. Bolivar, Andres R. Alcantara, Javier Rocha-Martin, Roberto Fernandez-Lafuente
Summary: In this study, MANAE-vinyl sulfone (VS) agarose beads were found to be a better support for immobilizing PGA enzyme compared to agarose-VS beads. The modified beads allowed for rapid and covalent immobilization of PGA, resulting in improved stability compared to low ionic strength VS-agarose.
Article
Chemistry, Physical
Oussama Khiari, Nassima Bouzemi, Jose Maria Sanchez-Montero, Andres R. Alcantara
Summary: In this paper, the authors study the combination between different chain sizes of orthoesters and an organic solvent mixture. These orthoesters act as water trappers and alcohol releasers during the enzymatic kinetic resolution of rac-ibuprofen. By using these orthoesters in the presence of a cosolvent, an improvement in enantioselectivity and enantiomeric excess of the target compound is achieved.
Article
Chemistry, Physical
Jose R. Guimaraes, Diego Carballares, Javier Rocha-Martin, Andres R. Alcantara, Paulo W. Tardioli, Roberto Fernandez-Lafuente
Summary: The lipase from Thermomyces lanuginosus (TLL) was immobilized on a methacrylate macroporous resin coated with octadecyl groups for enhanced stability. Covalent immobilization of the enzyme was achieved by activating the support with divinyl sulfone. The use of different blocking agents affected the functional features of the biocatalyst.
Review
Pharmacology & Pharmacy
Juan D. Sanchez, Andres R. Alcantara, Juan F. Gonzalez, Jose Maria Sanchez-Montero
Summary: Alzheimer's disease is a multifactorial neurodegenerative disorder that can be divided into two target clusters based on the affected proteins. Heterocyclic systems have great potential as potential drug candidates with multi-target capacity for this disease.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Oussama Khiari, Nassima Bouzemi, Jose Maria Sanchez-Montero, Andres R. Alcantara
Summary: An easy and versatile method was developed to obtain lipase-based cross-linked-enzyme aggregate-like copolymers (CLEA-LCs) using consecutive cross-linking steps with two types of cross-linkers and mediated by amine activation. Six lipases were tested, and all showed good retention of catalytic properties, improved thermal and storage stability. Notably, CLEA-LCs derived from Candida rugosa lipase displayed excellent thermostability and enantioselectivity in catalyzing the hydrolysis of racemic ibuprofen ethyl ester.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Cecilia Garcia-Oliva, Alejandro Merchan, Almudena Perona, Pilar Hoyos, Angel Rumbero, Maria J. Hernaiz
Summary: Two green strategies, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, based on two activation pathways, for copper-catalyzed azide-alkyne cycloaddition reaction were reported. Glucuronic acid glycodendrimers were synthesized with good conversions (99%), with the microwave pathway being the ideal tool (90% yield in 90 min).
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
