Article
Fisheries
Hang Hu, Xinshan Zhao, Shengkang Li, Yi Gong
Summary: The study identified SpICAD in mud crabs as having an immunoregulatory role during WSSV infection by inhibiting apoptosis, ultimately promoting virus replication. These findings offer new insights into the anti-viral immune response of mud crabs.
Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Agriculture, Dairy & Animal Science
Po-Tsang Lee, Jing Huang, Chin-Yi Huang, Zi-Xuan Liu, Han-Yang Yeh, Huai-Ting Huang, Li-Li Chen, Fan-Hua Nan, Meng-Chou Lee
Summary: The study demonstrates that phycoerythrin from Colaconema sp. can act as an immunomodulator in whiteleg shrimp, enhancing immune gene expression and innate immune parameters to increase survival rates when challenged with viruses or bacteria.
Article
Biochemical Research Methods
Paula J. Segura-Ramirez, Pedro Machado de Godoy, Ivan N. Avino, Pedro I. Silva Junior
Summary: The study identified several native peptides with antimicrobial activity in the hemolymph of the millipede Rhincricus sp., suggesting the potential for developing unconventional antibiotics. These peptides may be encrypted in large plasma proteins and future research should focus on elucidating their mechanisms of action and additional biological properties.
JOURNAL OF PROTEOMICS
(2021)
Article
Fisheries
Won Je Jang, Su-Jeong Lee, Mi-Hyeon Jeon, Tae-Yong Kim, Jong Min Lee, Md Tawheed Hasan, Hyun-Tai Lee, Jung-Ha Park, Bong-Joo Lee, Sang Woo Hur, Seunghan Lee, Kang Woong Kim, Eun-Woo Lee
Summary: This study confirmed the safety of KRF-7 isolated from rockfish intestines and suggested that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of intestinal microbiota and immune response.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Microbiology
Eleonora Rolli, Axel de Zelicourt, Hanin Alzubaidy, Michael Karampelias, Sabiha Parween, Naganand Rayapuram, Baoda Han, Katja Froehlich, Aala A. Abulfaraj, Hanna Alhoraibi, Kiruthiga Mariappan, Cristina Andres-Barrao, Jean Colcombet, Heribert Hirt
Summary: Research findings suggest that the endophyte Enterobacter sp. SA187 can trigger immune responses in Arabidopsis, but only at high concentrations, possibly due to its ability to evade or suppress the plant defense system. Transcriptome analysis revealed that LYK4 plays a crucial role in balancing plant immunity and growth and development processes, affecting the plant's resistance to salt stress.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Oncology
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R. Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A. Morse, Zachary Conrad Hartman
Summary: This study demonstrates that the suppression of innate immune gene expression in tumor cells is a major factor contributing to the insensitivity of colorectal cancer to immune checkpoint inhibitor treatment. By reintroducing the suppressed gene MAVS, the study found that it can stimulate both local and systemic immune responses against the tumor and enhance the efficacy of anti-tumor immunotherapy when combined with PD-L1 inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Chemistry, Multidisciplinary
DaeYong Lee, Kristin Huntoon, Yifan Wang, Wen Jiang, Betty Y. S. Kim
Summary: The discovery of immune checkpoint blockade has revolutionized cancer treatment, but current immunotherapies are only effective for a small subset of patients. Future advancements in cancer immunotherapy will focus on developing novel therapeutic molecules or immunoengineered cells. Biomaterials can efficiently reprogram and recruit immune cells in tumors to activate T cell immunity against advanced cancers.
ADVANCED MATERIALS
(2021)
Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope K. Blakely, Ayse Bilge Ozel, Sarah E. Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekumulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstrom, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Immunology
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson
Summary: Alcohol use can impact the function of both innate and adaptive immune cells, leading to immune dysfunction and organ damage. The role of innate lymphocytes, particularly liver-resident natural killer cells, in alcohol-induced pathogenesis is of increasing interest. However, the specific role of innate lymphocytes in alcohol-induced end-organ damage remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Microbiology
Eva Burger
Summary: Protective immunity against Paracoccidioides involves a stepwise activation of various cellular and soluble components, starting with non-specific innate immunity, followed by the role of specific antibodies and the mechanisms of cellular immunity.
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. While they can evade the immune system, they are recognized by the innate immune system, leading to inflammation. Recent studies have found that inflammasome signaling plays a role in herpesvirus innate immune activation and impacts disease outcomes.
Article
Biochemistry & Molecular Biology
Anuradha Ray, Sagar L. Kale, Richard P. Ramonell
Summary: Despite advancements in pulmonary immunology, there is still much work to be done in understanding coordinated immune responses in the lung. The SARS-CoV-2 pandemic has shown the inadequacy of current models of host-pathogen interactions and emphasized the importance of unraveling complex biological questions for immunologists. The 64th Annual Thomas L. Petty Aspen Lung Conference focused on bridging the gap between innate and adaptive immunity in the lung, discussing disease pathogenesis, immune responses, autoimmune lung diseases, immunologic cancer treatments, and new paradigms for lung disease prevention and treatment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Masato Ogura, Haruhisa Kikuchi, Norshalena Shakespear, Toshiyuki Suzuki, Junko Yamaki, Miwako K. Homma, Yoshiteru Oshima, Yoshimi Homma
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Haruhisa Kikuchi, Kosuke Kawai, Yota Nakashiro, Takayuki Yonezawa, Kumi Kawaji, Eiichi. N. Kodama, Yoshiteru Oshima
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Correction
Chemistry, Organic
Takehiro Nishimura, Junya Kawai, Yoshiteru Oshima, Haruhisa Kikuchi
Article
Biotechnology & Applied Microbiology
Toshihiko Nogawa, Makoto Kawatani, Akiko Okano, Yushi Futamura, Harumi Aono, Takeshi Shimizu, Naoki Kato, Haruhisa Kikuchi, Hiroyuki Osada
JOURNAL OF ANTIBIOTICS
(2019)
Article
Nutrition & Dietetics
Daiki Nakahara, Cui Nan, Koichiro Mori, Motoki Hanayama, Haruhisa Kikuchi, Shizuka Hirai, Yukari Egashira
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Medicine, Research & Experimental
Jing Zhang, Osamu Yamada, Shinya Kida, Shinya Murase, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuchi
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Hitomi Sasaki, Yuzuru Kubohara, Hirotaka Ishigaki, Katsunori Takahashi, Hiromi Eguchi, Akihiro Sugawara, Yoshiteru Oshima, Haruhisa Kikuchi
Article
Biochemistry & Molecular Biology
Yuzuru Kubohara, Yoshimi Homma, Hiroshi Shibata, Yoshiteru Oshima, Haruhisa Kikuchi
Summary: DIF-1 and DIF-1(3M) promote glucose uptake and metabolism via an AMPK-dependent pathway in 3T3-L1 cells, potentially serving as leading antiobesity and antidiabetes compounds, whereas CP-DIF-1 had no effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Palak Babbar, Mizuki Sato, Yogavel Manickam, Siddhartha Mishra, Karl Harlos, Swati Gupta, Suhel Parvez, Haruhisa Kikuchi, Amit Sharma
Summary: Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) is a potential therapeutic target for anti-malarial treatment. Cladosporin has been identified as a potent inhibitor of PfKRS, and in this study, analogues with a piperidine ring replacing the tetrahydropyran (THP) frame of cladosporin were synthesized and evaluated. The compounds showed moderate potency in binding to and inhibiting PfKRS, providing a basis for further development of this scaffold as a lead compound.
Article
Pharmacology & Pharmacy
Toshihiro Mita, Makoto Hirai, Yoshiko Maki, Saifun Nahar, Naoko Yoshida, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara
Summary: The study showed that DIF-1 and its derivatives have strong inhibitory effects on the growth of Plasmodium falciparum, including strains resistant to chloroquine and artemisinin. Among them, DIF-1(+2) exhibited the strongest inhibitory effect and was effective against 12 field isolates. In in vivo experiments in mice, DIF-1(+2) at certain doses effectively suppressed parasite growth without apparent adverse effects, and significantly prolonged animal survival.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shoji Kokubo, Shinobu Ohnuma, Megumi Murakami, Haruhisa Kikuchi, Shota Funayama, Hideyuki Suzuki, Taiki Kajiwara, Akihiro Yamamura, Hideaki Karasawa, Norihiko Sugisawa, Kosuke Ohsawa, Kuniyuki Kano, Junken Aoki, Takayuki Doi, Takeshi Naitoh, Suresh V. Ambudkar, Michiaki Unno
Summary: This study identified a novel ABCG2 inhibitor, PFC, through high-throughput screening, which significantly decreased IC50 of SN-38 in cancer cells and reversed resistance to irinotecan without causing toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Toru Higashinakagawa, Haruhisa Kikuchi, Hidekazu Kuwayama
Summary: The study attempted to identify the active principle EMF in EM culture extract, and found that the stimulatory effect in EM mainly resides in the residual insoluble material, composed of micro particles containing magnesium and potassium. Acid treatment of the residue produced air bubbles, indicating the presence of inorganic carbonate in the particles, which are believed to be the active principle of EM culture extract.
Article
Chemistry, Multidisciplinary
Yoshihide Suzuki, Keisuke Ichinohe, Akihiro Sugawara, Shinya Kida, Shinya Murase, Jing Zhang, Osamu Yamada, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuchi
Summary: In this study, novel immune checkpoint inhibitors with enhanced potency were developed through modifications of an existing unnatural pentacyclic compound. These inhibitors showed the ability to suppress both CTLA-4 and PD-L1 gene expression and protein expression, making them the first reported dual small-molecule inhibitors of CTLA-4 and PD-L1.
FRONTIERS IN CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, Kazuhiko Seya, Tadaatsu Imaizumi
Summary: The study found that resveratrol and its derivatives can regulate the innate immune system by inhibiting the phosphorylation of the transcription factor NF-KB, thereby suppressing inflammatory reactions. These findings are important for the development of drugs for the prevention and treatment of autoinflammatory and autoimmune diseases.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
