4.4 Article

Nucleophilic addition to 2,3-pyridyne and synthesis of benzonaphthyridinones

Journal

TETRAHEDRON
Volume 68, Issue 13, Pages 2819-2826

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.02.002

Keywords

2,3-Pyridyne; Amination; Annulation; Benzonaphthyridinone; Heterocycle

Funding

  1. National Science Foundation
  2. National Institutes of Health Center of Excellence for Chemical Methodology and Library Development at the University of Kansas [P50 GM069663]

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A study of the nucleophilic addition of amines to 2,3-pyridyne has been carried out. 2-Aminopyridines have been generated exclusively. A series of benzonaphthyridinones have been synthesized by reacting 2,3-pyridyne and o-aminobenzoates. (C) 2012 Elsevier Ltd. All rights reserved.

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