Journal
TETRAHEDRON
Volume 67, Issue 14, Pages 2689-2692Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.01.045
Keywords
CAL-B; Hantzsch-type reaction; Acetamide; 1,4-dihydropyridines; Non-aqueous solvent; Enzyme-catalyzed
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Funding
- National Natural Science Foundation of China [20704037, 20872130, 20874086]
- Zhejiang Provincial Natural Science Foundation [2009Y4080198, 2010-Z4090225]
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A direct approach to 1,4-dihydropyridines by lipase-catalyzed unprecedented three-component Hantzschtype reaction of aldehyde with 1,3-dicarbonyl compounds and acetamide in non-aqueous solvent has been developed. Some control experiments have been performed to demonstrate the specific catalytic effect of CAL-B. Acetamide was utilized as a novel ammonia source in the Hantzsch-type reaction for the first time. An array of 1,4-dihydropyridines was successfully synthesized through this methodology. (C) 2011 Elsevier Ltd. All rights reserved.
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