Journal
TETRAHEDRON
Volume 67, Issue 49, Pages 9582-9587Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.09.137
Keywords
Enzymatic reactions; Promiscuity; Multistep conversions; One-pot synthesis; Tetrahydrochromene derivatives
Categories
Funding
- National Natural Science Foundation of China [21076052]
- Science and Technology Plan of Zhejiang Province [2011C24004]
- Key Sci-tech Innovation Team of Zhejiang Province [2010R50017]
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An efficient and green one-pot synthesis route for tetrahydrochromene derivatives was developed. Lipase from Porcine pancreas (PPL) shows excellent catalytic activity and exerts good adaptability to different substrates in the reaction. All the reactions go smoothly and provide tetrahydrochromene derivatives with isolate yield up to 97% under room temperature. This lipase-catalyzed multistep conversion method has provided a new strategy to synthesize chromene derivatives and expanded the application of enzyme in organic synthesis. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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