Article
Chemistry, Analytical
Vincen Wu, Jocelyn Tillner, Emrys Jones, James S. McKenzie, Dipa Gurung, Anna Mroz, Liam Poynter, Daniel Simon, Cristina Grau, Xavier Altafaj, Marc-Emmanuel Dumas, Ian Gilmore, Josephine Bunch, Zoltan Takats
Summary: This study examines the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) of biological tissue, comparing its performance to the traditional desorption electrospray ionization (DESI). The flow focusing mechanism in DESI offers advantages such as a rotationally symmetric electrospray jet, higher intensity, controllable parameters, and better portability. The optimized parameters for DEFFI result in similar images to DESI but with better sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Ricardo Alves Bernardo, Jean Carlos Pereira Sousa, Matheus Gallimberti, Fernando Barbosa Junior, Boniek Gontijo Vaz, Andrea Rodrigues Chaves
Summary: Concerns over human health risks due to the use of bisphenol A in thermal papers have led to its replacement by bisphenol S. Analyzing bisphenols typically involves laborious and time-consuming steps, but a new paper spray ionization mass spectrometry (PSI-MS) method offers a faster and efficient alternative. The study found that bisphenol S concentrations in BPA-free thermal papers ranged from 1.36 to 6.77 mu g g(-1), while BPA concentrations in all samples of thermal paper ranged from 6.56 to 16.4 mu g g(-1).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Thi Minh Hoa Nguyen, Woo-Young Song, Tae-Young Kim
Summary: This study systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI) and classified the observed paper spray plume into three modes. The rim-jet mode exhibited the highest ionization efficiency among the three modes. The charge density of the droplets generated by paper spray, influenced by the electric field and solvent supply rate, was found to be the main parameter determining the spray mode.
FRONTIERS IN CHEMISTRY
(2022)
Article
Geochemistry & Geophysics
Yankun Di, Evgenii Krestianinov, Sonja Zink, Yuri Amelin
Summary: High-precision measurement of Sr-84/Sr-86 variations using TIMS is crucial for understanding planetary volatile depletion history and isotopic reservoirs in the early Solar System. Discrepancies between static and multidynamic TIMS measurements indicate biases, with fractionation drift significantly affecting the Sr-84/Sr-86 ratio. Corrections for these effects reveal an accurate average mu Sr-84 value for terrestrial samples and highlight differences between standard and natural samples.
Article
Chemistry, Organic
Boyu Zheng, Yikang Wu, Luyun Xue, Jiannan Sun, Jinhua Liu, Heyong Cheng
Summary: Microdroplet chemistry accelerates chemical and biological reactions, but its impact on retaining chiral centers and controlling enantioselectivity varies. In asymmetric catalysis, microdroplet chemistry harms the stereospecificity of chiral catalysts and chiral organic ligands.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qiong Liang, Siyu Liu, Wei Xu, Yanbing Zhai
Summary: In this study, a capillary-in-capillary electrospray ionization (CC-ESI) source was developed for spontaneous liquid sampling and quantitative analysis based on the capillary phenomenon and electrospray ionization mass spectrometry (ESI-MS). The CC-ESI had advantages of cheap price, high portability, disposability, quantitation capability, and adequate sensitivity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wei Zhou, Janusz Pawliszyn
Summary: This paper presents a new coated blade spray design that improves the stability and reproducibility of mass spectrometry analysis in negative ionization mode. The design features a barrier at the far end of the electrospray ionization (ESI) tip and allows for fast screening and quantitative analysis of target analytes in complex matrices without the use of internal standards.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ping Guo, Ke Min, Wei Luo, Si Huang, Zihui Yang, Ming Ma, Shubin Liu, Zhengfa Fang, Bo Chen, Han Zuilhof
Summary: Ambient ionization of glycans can be achieved efficiently by spraying from a paper surface impregnated with alkali metal salt. This method allows for the formation of abundant alkali metal adduct ions from monosaccharides, oligosaccharides, and ring glycans, resulting in simple and clean mass spectra. The approach is specific for glycans and has been successfully applied in the determination of glycans and glycoconjugates in various biological matrices.
Article
Biochemistry & Molecular Biology
Thomas Michael Muggli, Stefan Schurch
Summary: The swab spray ionization method for sampling fruit surfaces and subsequent ionization offers a quick and effective way for screening and quantitating pesticide residues. It addresses issues related to sample collection, swab background, solvent composition effects on adduct formation, and presents a novel quantitative approach based on depletion curve areas. Swab spray ionization is demonstrated as an efficient method for library-based identification and quantification of polar contact pesticide residues on food.
Article
Biochemistry & Molecular Biology
Youngju Kal, Sangwon Cha
Summary: Paper spray ionization (PSI) is an extractive ambient ionization technique for mass spectrometry, which can achieve the separation and detection of lipid mixtures. The study found that differential transport of lipid classes occurs during PSI, depending on the polarity of the spraying solvent and the method of application.
Article
Chemistry, Applied
Fabio Mazzotti, Lucia Bartella, Ines Rosita Talarico, Anna Napoli, Leonardo Di Donna
Summary: A fast and accurate methodology has been developed for quantifying the most abundant flavanone glycosides in citrus beverages using paper spray mass spectrometry. The experimental results demonstrate the method's high specificity and sensitivity, making it suitable for practical applications. The comparison of real sample analysis with conventional chromatographic methods confirmed the robustness of the proposed approach.
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gesiane S. Lima, Gabriel F. dos Santos, Gagan Preet, Lanaia I. L. Maciel, Teresinha de Jesus A. S. Andrade, Marcel Jaspars, Andrea R. Chaves, Boniek G. Vaz
Summary: A combination of liquid chromatography electrospray ionization and paper spray ionization high-resolution tandem mass spectrometry was used to analyze metabolite fingerprinting of cupuassu pulp extracts prepared with different solvents. Methanol was found to be effective in extracting phenols and cinnamic acids derivatives, while acetonitrile and acetonitrile/methanol were more effective in extracting terpenoids and flavonoids, respectively. Paper spray ionization tandem mass spectrometry showed potential as a screening technique. The study also identified major metabolites with antioxidant activity and generated a pharmacophore model for the design of new antioxidants.
Article
Chemistry, Analytical
Qi Hu, Meng Chen, Mengmeng Yan, Penglong Wang, Haimin Lei, Hongyu Xue, Qiang Ma
Summary: This study comprehensively analyzed the chemical compositions of Sini decoction and identified 99 compounds using advanced techniques. The study also explored the formation of complexes between phytochemical ingredients, providing insights into the therapeutic relevance of the decoction.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Jong-Ho Park
Summary: In this study, isotopic analysis of ultra-trace uranium was performed using TIMS and the data integration process was optimized. Method III was recommended for its accuracy and precision in individual microparticle analysis by TIMS.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Madison E. Pursell, Daud Sharif, Anthony DeBastiani, Chong Li, Sandra Majuta, Peng Li, Stephen J. Valentine
Summary: The new ionization technique, vibrating sharp-edge spray ionization (cVSSI), coupled with corona discharge, has been investigated for its atmospheric pressure chemical ionization (APCI) capabilities. The optimized source has shown improved ion signal intensity, overcoming of matrix effects, and limitation of ion suppression, compared to the state-of-the-art ESI source and a new APCI-like source. The results demonstrate significant enhancements in ion signal intensity and abilities to overcome ion suppression in both methanol and aqueous samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
