Review
Integrative & Complementary Medicine
Sun Fu-Juan, Li Min, Gu Liang, Wang Ming-Ling, Yang Ming-Hua
Summary: Candida is a difficult-to-eradicate life-threatening pathogen causing major morbidity and mortality in immunocompromised individuals. The rapid spread of drug-resistant fungi has highlighted the urgent need for new anti-Candida agents. Researchers have made important progress in discovering novel antifungal agents from nature to combat this medical challenge.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Biochemistry & Molecular Biology
Aqsa Mushtaq, Ameer Fawad Zahoor, Muhammad Bilal, Syed Makhdoom Hussain, Muhammad Irfan, Rabia Akhtar, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Summary: Sharpless asymmetric dihydroxylation is an important reaction in enantioselective synthesis of chiral vicinal diols. It involves the treatment of alkene with osmium tetroxide and optically active quinine ligand. This review highlights the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products since 2020.
Article
Agriculture, Multidisciplinary
Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang, Ying-Qian Liu, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan
Summary: This study synthesized and tested 30 magnolol derivatives based on natural products, with 11 compounds showing potential antifungal activity against four plant pathogenic fungi. Compound L5 exhibited strong antifungal properties against Botrytis cinerea, suggesting it as a promising candidate for crop protection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Microbiology
Arumugam Ganeshkumar, Juliana Caparroz Goncale, Rajendran Rajaram, Juliana Campos Junqueira
Summary: This review discusses the significance of marine natural products in controlling the proliferation and metabolism of Candida species, including drug-resistant strains. It highlights the research value of sponges that produce compounds with inhibitory activity against Candida strains. Additionally, the review reveals the mechanisms and synergistic activity of marine products with conventional antifungals. Overall, the majority of compounds derived from the marine environment are capable of controlling specific functions of Candida microorganisms, providing insights into the design of new anti-candidal therapies.
Article
Chemistry, Multidisciplinary
Xin Shu, Chong-Chong Chen, Tao Yu, Jiayi Yang, Xiangdong Hu
Summary: Spiroxins A, C, and D are metabolites identified in the marine fungal strain LL-37H248, with unique polycyclic structures and intriguing biological activities. Researchers achieved the enantioselective total synthesis of (-)-spiroxins A and C, as well as the first total synthesis of (-)-spiroxin D, through a series of reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Tom D. D'Arcy, Mark R. J. Elsegood, Benjamin R. Buckley
Summary: The highly enantioselective organocatalytic tandem o-HPD-[4+2] reaction described offers a practical method for the synthesis of complex scaffolds. This approach utilizes a chiral oxaziridinium organocatalyst to afford dearomatized products in high enantioselectivity, demonstrating its potential for gram-scale applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Microbiology
Stephan Brinkmann, Michael Kurz, Maria A. Patras, Christoph Hartwig, Michael Marner, Benedikt Leis, Andre Billion, Yolanda Kleiner, Armin Bauer, Luigi Toti, Christoph Poeverlein, Peter E. Hammann, Andreas Vilcinskas, Jens Glaeser, Marius Spohn, Till F. Schaeberle
Summary: The availability of publicly accessible bacterial genomes has facilitated the use of bioinformatics tools for genome mining, allowing for the exploration of natural product biosynthesis capabilities. In this study, the genetic potential of the Bacteroidetes phylum was comprehensively analyzed, revealing the Chitinophaga genus as the most talented in terms of biosynthetic gene cluster abundance and diversity. Metabolomics and bioactivity-driven NP discovery on 25 Chitinophaga strains confirmed the predicted biosynthetic potential and uncovered a vast unexplored chemical space. This study isolated new antibiotics called chitinopeptins with activity against Candida, highlighting the importance of mining underinvestigated microbial taxa for future screening and isolation campaigns.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Organic
Sheng Zuo, Yuan Tao, Zhigang Liu, Ke Zhang, Luyun Zhang, Yingtang Ning, Fen-Er Chen
Summary: This study successfully synthesized highly congested indanone-based spirolactones through copper-catalyzed decarboxylative propargylation, with the key role of DPEN-based ligands. The method tolerated a wide range of functional groups, yielding high diastereo- and enantioselectivities. Mechanistic observations indicated the capability of the new copper complex to enable stereocontrolled addition to copper-allenylidene species.
Article
Biochemistry & Molecular Biology
Raghav Vij, Bernhard Hube, Sascha Brunke
Summary: Fungal infections are a serious issue and bacteria continue to be an important source of antifungals. Research on ecological bacterial-fungal interactions is needed to develop new strategies for treating fungal infections.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Agriculture, Multidisciplinary
Yu-Bin Bai, Meng Zhang, Ding Li, Yu Zhao, Liang-Zhu Huang, Jin-Ming Gao
Summary: Researchers synthesized 39 diversified griseofulvin derivatives and found that compounds 5h and 5l exhibited excellent antifungal activity against two phytopathogenic fungi. Compounds 9, 10, 11, and 12 also showed potential antifungal activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Georg Niggemeyer, Anastasia Knyazeva, Raphael Gasper, Dale Corkery, Pia Bodenbinder, Julian J. Holstein, Sonja Sievers, Yao-Wen Wu, Herbert Waldmann
Summary: Design and synthesis of pseudo-natural products through recombination of natural product fragments enables the discovery of novel biologically relevant chemical matter. In this study, the combination of this principle with macrocycle formation was described, leading to the efficient synthesis of 163 macrocyclic pseudo-natural products. Biological investigation revealed their potent inducers of autophagy-related processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Yanan Du, Anyarat Thanapipatsiri, Kenichi Yokoyama
Summary: Nucleoside natural products have diverse biological activities and can be used for various applications, including medicine and agriculture. Previous studies have revealed the biosynthetic mechanisms of these nucleosides, involving early steps classified into two types and downstream tailoring enzymes for structural diversity. By investigating two enzymes representing these types of modifications, it is possible to discover putative nucleoside biosynthetic gene clusters and predict core nucleoside structures, suggesting the potential for future discovery of novel nucleoside natural products.
Review
Plant Sciences
M. Angeles Curto, Estefania Butassi, Juan C. Ribas, Laura A. Svetaz, Juan C. G. Cortes
Summary: Systemic fungal infections related to immunosuppressive therapies have become a serious healthcare problem in the last three decades, calling for the urgent development of new antifungals. This review focuses on the discovery of natural products from plants that can inhibit cell wall synthesis targets, aiming to identify potential candidates for antifungal drug development. Through an extensive systematic search, articles on natural antifungals from plants targeting fungal cell wall synthesis were found, with some showing inhibition of both GS and CS activities.
Review
Chemistry, Multidisciplinary
Debobrata Paul, Ashis Kundu, Sanu Saha, Rajib Kumar Goswami
Summary: This feature article highlights total synthesis as a reliable tool for confirming the structure of natural products. Despite advances in spectroscopic techniques, structural misassignments of natural products remain common. Recent case studies have shown that chemical synthesis can be used to revise the structures of natural products.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Tian-Jiao Han, Chun-Yan Guan, Na Li, Rui Dong, Li-Ping Xu, Xiao Xiao, Min-Can Wang, Guang-Jian Mei
Summary: A highly efficient dynamic kinetic resolution protocol for the atroposelective synthesis of heterobiaryls with vicinal C-C and N-N diaxes is reported. The combination of C-C biaryl with N-N nonbiaryl enables the synthesis of a novel class of vicinal-diaxis heterobiaryls.
Article
Polymer Science
Kalpana Handore, Dipak Walunj, Prakash Chhattise, Aniruddha Chabukswar, Kakasaheb Mohite, Sabrina Dallavalle, Bahule Bharat, Vasant Chabukswar
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
(2017)
Article
Chemistry, Organic
Rahul D. Kaduskar, Andrea Pinto, Leonardo Scaglioni, Loana Musso, Sabrina Dallavalle
SYNTHESIS-STUTTGART
(2017)
Article
Pharmacology & Pharmacy
Paola Tiberio, Elena Cavadini, Loredana Cleris, Sabrina Dallavalle, Loana Musso, Maria G. Daidone, Valentina Appierto
FRONTIERS IN PHARMACOLOGY
(2017)
Meeting Abstract
Oncology
Claudio Pisano, Lucio Merlini, Sergio Penco, Raffaella Cincinelli, Nadine Darwiche, Mario B. Guglielmi, Ilaria La Porta, Giacomo Signorino, Gabriele De Rubis, Fabiana Colelli, Francesco Cardile, Alessandra Fucci, Egildo L. D'Andrea, Sabrina Dallavalle
Article
Biology
Cristina Visentin, Loana Musso, Luca Broggini, Francesca Bonato, Rosaria Russo, Claudia Moriconi, Martino Bolognesi, Elena Miranda, Sabrina Dallavalle, Daniele Passarella, Stefano Ricagno
Review
Biochemistry & Molecular Biology
Loana Musso, Andrea Fabbrini, Sabrina Dallavalle
Article
Biochemistry & Molecular Biology
Sabrina Dallavalle, Luce M. Mattio, Roberto Artali, Loana Musso, Anna Avino, Carme Fabrega, Ramon Eritja, Raimundo Gargallo, Stefania Mazzini
Summary: The study revealed the DNA binding properties of curaxin CBL0137 with G-quadruplex, providing insights for the design of novel selective DNA-targeting curaxin analogues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Dallavalle, Salvatore Princiotto, Luce M. Mattio, Roberto Artali, Loana Musso, Anna Avino, Ramon Eritja, Claudio Pisano, Raimundo Gargallo, Stefania Mazzini
Summary: DNA repair inhibitors, particularly PARP1 inhibitors, have emerged as a new approach in cancer chemotherapy. Recent studies have shown that certain PARP1 inhibitors can form defined complexes with G-quadruplex structures within the PARP1 gene promoter, suggesting the potential development of better binders to inhibit the enzyme activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Catinella, Silvia Donzella, Gigliola Borgonovo, Sabrina Dallavalle, Martina Letizia Contente, Andrea Pinto
Summary: OLE is the most abundant phenolic compound in olive trees and has various biological actions. HT, the main degradation product of OLE, is a powerful antioxidant agent. The two-step biotransformation method efficiently transforms OLE into HT, resulting in a high yield of HT that can be commercialized as a natural product.
Article
Biochemistry & Molecular Biology
Fabio Magurano, Marzia Sucameli, Pasquale Picone, Matteo Micucci, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Giorgia Catinella, Gigliola Borgonovo, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto
Summary: The COVID-19 pandemic continues to pose a threat to public health, with a recent discovery linking severe infection risk to high oxidative stress levels. Research on grapefruit seed extracts and their components has revealed remarkable antiviral, antioxidant, and mitoprotective properties.
Article
Biochemistry & Molecular Biology
Stefania Mazzini, Salvatore Princiotto, Loana Musso, Daniele Passarella, Giovanni Luca Beretta, Paola Perego, Sabrina Dallavalle
Summary: In this study, a new class of potential G-quadruplex stabilizing molecules was developed by conducting structural modifications on existing derivatives, and it was found that a planar structure and charged nitrogen-containing groups facilitated the binding to G-quadruplex grooves and loops.
Article
Biochemistry & Molecular Biology
Stefania Mazzini, Salvatore Princiotto, Roberto Artali, Loana Musso, Anna Avino, Ramon Eritja, Raimundo Gargallo, Sabrina Dallavalle
Summary: PARP1 enzyme is an attractive target for cancer therapy due to its involvement in DNA repair processes. However, the effectiveness of PARP1 inhibitors is being threatened by the emergence of resistance, necessitating the search for alternative strategies to selectively regulate PARP1 activity. A recent study identified a noncanonical G-quadruplex-forming sequence within the PARP1 promoter. This study explores the interaction between known G-quadruplex binders and the G-quadruplex structure found in the PARP gene promoter region, demonstrating various binding modes with small stabilization of the G-quadruplex sequence. Surprisingly, only pyridostatin produces a strong stabilization of the G-quadruplex-forming sequence.
Article
Biochemistry & Molecular Biology
Sabrina Dallavalle, Roberto Artali, Salvatore Princiotto, Loana Musso, Gigliola Borgonovo, Stefania Mazzini
Summary: G-quadruplexes are important nucleotide sequences that control gene transcription, and the affinity of dye compounds from Aloe vera to G-quadruplex structures has been studied. The results confirm previous findings and provide new interaction models to search for more stable nature-derived compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Peter Riber Johnsen, Cecilia Pinna, Luce Mattio, Mathilde Bech Strube, Mattia Di Nunzio, Stefania Iametti, Sabrina Dallavalle, Andrea Pinto, Hanne Frokiaer
Summary: This study compares the effects of seven different structural types of stilbenoids on the modulation of cytokine production and antioxidant response. Monomeric compounds showed dose-dependent inhibition of cytokine production induced by E. coli, with resveratrol and piceatannol also inhibiting IL-10 production. All monomers, except trimethoxy-resveratrol, inhibited cytokine production induced by L. acidophilus. However, the dimer dehydro-delta-viniferin remarkably enhanced IL-12 production induced by L. acidophilus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
Claudio Pisano, Lucio Merlini, Sergio Penco, Raffaella Cincinelli, Nadine Darwiche, Mario B. Guglielmi, Ilaria La Porta, Maddalena Pizzulo, Federica Prosperi, Giacomo Signorino, Fabiana Colelli, Francesco Cardile, Laura Focareta, Alessandra Fucci, Egildo L. D'Andrea, Assunta Riccio, Sabrina Dallavalle
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
