Article
Chemistry, Inorganic & Nuclear
Harish S. Kunchur, Maravanji S. Balakrishna
Summary: The reactions of amide functionalized bisphosphine with platinum salts were studied, resulting in the formation of various complexes. The mechanism of the formation of 1,2-azaphospholene was investigated. Additionally, a palladium complex with low catalyst loading showed excellent catalytic activity in the N-alkylation reaction of amines with alcohols.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Vinothkumar Vinayagam, Satish Kumar Karre, Sreenivasa Reddy Kasu, Ravuri Srinath, Hema Sundar Naveen Babu Bathula, Subir Kumar Sadhukhan
Summary: In this study, a transition-metal-free frustrated Lewis pair (FLP) catalyzed reaction was reported for the first time, enabling the migration of CHF2 group from an oxygen atom to the neighboring nitrogen atom. The reaction resulted in the synthesis of N-substituted benzimidazoles at room temperature, with excellent yields, broad functional group tolerance, and a short reaction time.
Article
Chemistry, Organic
Liang-Hua Zou, Biao Liu, Cheng Wang, Zeyu Shao, Junqi Zhou, Andong Shao, Jian Wen
Summary: An efficient and green method for synthesizing various alkyl amines through the cleavage of vinylsulfonium salts' C(sp(3))-S bond has been developed. This reaction can be conducted under air atmosphere and shows a broad range of applicability with N-nucleophiles. Additionally, N-vinylazoles can be obtained with moderate to good yields through the reaction of vinylsulfonium salts with N-containing heterocycles in the presence of a base at room temperature.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
V Murugesh, Apurba Ranjan Sahoo, Mathieu Achard, Gangavaram V. M. Sharma, Christian Bruneau, Surisetti Suresh
Summary: In this study, a ruthenium-catalyzed regioselective beta-C(sp(3))-H bond functionalization on the piperazine core using aldehydes as alkylating agents was disclosed. The transformation involves dehydrogenation of piperazine to enamine in situ, nucleophilic addition to aldehyde, and hydrogenation to achieve regioselective beta-C(sp(3))-H alkylation. Various aromatic, heteroaromatic, and aliphatic aldehydes were employed for the C-3 alkylation of N-alkyl-N'-p-nitrophenyl substituted piperazines.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Vinita Yadav, Sayali G. Jagtap, Ekambaram Balaraman, Santosh B. Mhaske
Summary: A novel method for the synthesis of N-substituted indoles under additive and base-free conditions is reported. The method utilizes a one-pot cascade approach with water as the only stoichiometric byproduct. The catalytic system used in this transformation exhibits high efficiency. A diverse range of N-alkylated indoles can be synthesized using various substrates.
Article
Chemistry, Organic
Lin Zhang, Qian Chen, Linlin Li, Nana Ma, Jie Tian, Hao Sun, Qian Xu, Yuanyong Yang, Chun Li
Summary: Unprecedented metal-free synthesis of both Nunsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones from o-aminobenzamides and CO2 under atmospheric pressure at room temperature is developed. This protocol allows for easy variations of functional groups at the N3-position to accommodate the construction of many important drugs and bioactive compounds. The reaction is eco-friendly, versatile, and can be scaled up to gram scale.
Article
Chemistry, Organic
Lin Zhang, Qian Chen, Linlin Li, Nana Ma, Jie Tian, Hao Sun, Qian Xu, Yuanyong Yang, Chun Li
Summary: The unprecedented metal-free synthesis of both Nunsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones from o-aminobenzamides and CO2 under atmospheric pressure at room temperature is developed. This protocol easily allows for variations of functional groups (including alkyl, aryl, and heterocycle groups) at the N3-position to accommodate the construction of many important drugs and bioactive compounds. The reaction features eco-friendliness, substrate scope tolerance, and versatility and can be implemented even at the gram scale.
Article
Chemistry, Multidisciplinary
Wei Tian, Bowen Li, Duanshuai Tian, Wenjun Tang
Summary: A palladium-catalyzed 2-alkylation of indoles with alpha-bromo esters using a P,P=O ligand has been developed. The method shows excellent regioselectivities, mild reaction conditions, and good functional group compatibility. Mechanistic studies indicate that the reaction proceeds through a radical pathway.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Organic
Xiaopeng Zhang, Jinjun Wang, Jiahui Xu, Qiuyang Pang, Dan Liu, Guisheng Zhang
Summary: An unprecedented Pd(II)-catalyzed cascade annulation of o-aminobenzoic acids with CO, amines, and aldehydes has been developed. This method provides an efficient and concise approach for the selective construction of N3-substituted and N1,N3-disubstituted 2,3-dihydroquinazolin-4(1H)-ones, mostly in moderate to excellent yields, from simple and easily available starting materials under mild conditions characterized by low cost, high step economy, broad substrate scope, and good product diversity.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Environmental Sciences
Zijun Pang, Yajuan Cai, Weihao Xiong, Junyang Xiao, Jing Zou
Summary: A new spectrophotometric method for measuring permanganate index in water was established, which showed high sensitivity, convenience in operation, and tolerance to interfering substances.
Article
Chemistry, Organic
Zhenliang Zhang, Xinliang Yao, Shuyan Li, Zhengbao Xu, Lizhi Zhang
Summary: An efficient and convenient method for selective oxidative functionalization of indoles using atmospheric O2 as the oxidant has been developed. The method shows good tolerance towards functional groups and can be applied to various indoles, giving moderate to good yields. It provides a sustainable and practical strategy for green oxidation of indoles, allowing the efficient synthesis of structurally important derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Priyanka Gupta, Hans-Joachim Drexler, Richard Wingad, Duncan Wass, Eszter Barath, Torsten Beweries, Christian Hering-Junghans
Summary: Phosphaalkenes are a new class of ligands similar to CO with unique electronic properties. We synthesized and characterized an iridium(I) complex with a phosphaalkene ligand, which showed versatile reactivity with different solvents or reagents. This complex exhibited good catalytic activity in the conversion of methanol and ethanol to iso-butanol, a promising biofuel candidate.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Subhro Mandal, Animesh Pramanik
Summary: The developed methodology involves a p-TsOH-mediated one-pot, three-component reaction to synthesize pyrrolo/indolo[1,2-a]quinoxalines substituted with various groups at the C-4 position under open-air heating conditions. The protocol provides a transition-metal-free and external oxidant-free pathway to generate a library of diversely substituted quinoxalines in moderate to good yields. X-ray crystal structure analysis indicates the possibility of atropisomerism in certain suitably substituted quinoxalines at room temperature.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Fang Liu, Zhi-Peng Ye, Yuan-Zhuo Hu, Jie Gao, Lan Zheng, Kai Chen, Hao-Yue Xiang, Xiao-Qing Chen, Hua Yang
Summary: A new methyl source, TMEDA, was identified and used to develop a protocol for direct C-H methylation of N-heteroarenes. The method features mild reaction conditions and a wide substrate scope.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Tao Li, Lin Dai, Yixin Huang, Siwen Pan, Zijun Pang, Jing Zou
Summary: A new spectrophotometric method for Cr(VI) determination was developed, showing rapid detection, high accuracy, and strong anti-interference ability. This method, based on the oxidative coloration of DPD and Cr(VI), demonstrated satisfactory accuracy in natural water samples and good anti-interference performance towards various common co-existing metallic ions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.