Journal
TETRAHEDRON
Volume 67, Issue 47, Pages 9185-9192Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.09.076
Keywords
Total synthesis; Marine natural product; Isoquinoline; Cribrostatin 4; Cytotoxicity
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [23590019, S0801043]
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [23590019] Funding Source: KAKEN
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A 19-step synthesis of (+/-)-cribrostatin 4 (1) from readily available piperazine-2,5-dione derivative 6 is described. The synthesis features the concise construction of a pentacyclic framework, followed by the base-catalyzed epimerization of the C-1 stereo center of aldehyde (11). The results of cytotoxicity studies are also presented. (C) 2011 Elsevier Ltd. All rights reserved.
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