Article
Chemistry, Applied
Andrei Baran, Mariia Babkova, Jana Petkus, Kirill Shubin
Summary: A convenient and general method for Suzuki-Miyaura double cross-coupling of various dibromothiophenes was developed. Using a simple and cheap catalytic system, diarylthiophenes, useful in the synthesis of metal-organic frameworks (MOFs), can be obtained in moderate to excellent yields. The efficiency of the catalytic process and excess of boronic acids help to suppress side products and simplify the purification of products.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sheng-Qi Qiu, Yu Chen, Xiang-Jun Peng, Shi-Jiang He, Jun Kee Cheng, Yong-Bin Wang, Shao-Hua Xiang, Jun Song, Peiyuan Yu, Junmin Zhang, Bin Tan
Summary: In this study, we achieved the arene-alkene Suzuki-Miyaura coupling reaction between hindered aryl halides and vinyl boronates by designing appropriate ligands and reaction parameters. The axially chiral acyclic aryl-alkenes obtained exhibited remarkable efficiency, enantioselectivity, and E/Z selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Vignesh Palani, Melecio A. Perea, Richmond Sarpong
Summary: This review discusses strategies for site-selective functionalization of polyhalogenated arenes and heteroarenes, including traditional reaction types and emerging strategies.
Article
Chemistry, Multidisciplinary
Matteo Albino, Thomas J. Burden, Carmen C. Piras, Adrian C. Whitwood, Ian J. S. Fairlamb, David K. Smith
Summary: The increase in demand and low abundance of palladium pose a significant threat to its future availability, making research into sustainable palladium-based technologies crucial. This study reports the development of Pd scavenging hybrid gel beads composed of agarose and a low-molecular-weight gelator based on DBS-CONHNH2. These mechanically robust gel beads exhibit potential as practical catalysts for Suzuki-Miyaura cross-coupling reactions, demonstrating good reusability, green metrics, and improved reaction times compared to previous examples. The leaching of palladium is almost completely eliminated and a detailed investigation explains how the nanoparticles are formed in situ. These ligand-free gel beads can be considered as robust nonligated heterogeneous PdNP catalysts with potential for the development of easily used chemical reaction systems.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Organic
Yong Zhou, Chenglong Ma, Dan Luo, Liangzhen Hu, Xiaohui Zhang, Xiaoyu Dong, Yan Xiong
Summary: A series of arylated [5]helicenes were effectively obtained through palladium catalyzed Suzuki-Miyaura reaction under mild conditions. The optical properties of [5]helicene derivatives were studied and showed red-shift compared to [5]helicene. This Pd-catalyzed coupling provides an effective protocol for the synthesis of mono-/bisalkyl [5]helicenes.
Article
Chemistry, Physical
Elvis N. Nishida, Elder C. Leopoldino, Laize Zaramello, Higor A. Centurion, Renato Goncalves, Ricardo F. Affeldt, Carlos E. M. Campos, Bruno S. Souza
Summary: A novel Pd(II)-polymeric pre-catalyst was successfully prepared and demonstrated good activity in the Suzuki-Miyaura coupling reaction. The catalyst showed recyclability and its performance was affected by the concentration of the cross-coupling partners. The presence of oxygen was found to be crucial in preventing the formation of inactive Pd(0) aggregates.
Article
Chemistry, Inorganic & Nuclear
Ceren Akpunar, Namik Ozdemir, Mert Olgun Karatas, Bulent Alici, Ismail Ozdemir
Summary: In this study, we synthesized five new coumarin-functionalised PEPPSI type Pd-NHC complexes to examine their catalyst properties. The complexes showed slightly distorted square-planar geometry and exhibited catalytic activity in the Suzuki-Miyaura reaction of phenylboronic acid and aryl bromide derivatives.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Orhan Altan
Summary: This study investigates the catalytic activity of Pd (II) complexes of phosphino-benzaldoxime ligands in Suzuki-Miyaura coupling reactions. The results show that reducing the amount of catalyst leads to an increase in catalytic activity, and it is found that palladium nanoparticles formed in the reaction medium are responsible for this activity. This study contributes to the debate over whether the catalytic activity of phosphine-palladium complexes in SMC reactions results from a homogeneous or heterogeneous pathway.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Julius Hoepfner, Marius Brehm, Pavel A. Levkin
Summary: The rising costs of pharmaceutical research are currently limiting the productivity of drug discovery and development, but can potentially be reduced through miniaturization of compound synthesis and screening. In this study, the influential palladium-catalyzed Suzuki-Miyaura reaction is successfully implemented at the nanoliter scale on droplet microarrays for the synthesis of an 800-compound library of biphenyls. The synthesis of these compounds requires minimal reagents and solvent volume, and the obtained compounds can be purified and cleaved from excess reactants and catalyst. This novel approach expands the capabilities of droplet microarrays for miniaturized high-throughput chemical synthesis and opens up possibilities for future synthesis and screening of chemical compounds in a single platform.
Article
Chemistry, Inorganic & Nuclear
Yida Wu, Xiao Feng, Qixiang Zhai, Haosen Wang, Huanfeng Jiang, Yanwei Ren
Summary: In this study, a metal-organic framework (MOF), MIL-101, was covalently grafted with the PPh3 ligand to form Pd/MIL-101-PPh3 nanocatalyst. Experimental results showed that the PPh3 on the MOF surface had an electron-donating effect, effectively activating the carbon-halogen bond in aryl halides. The Pd/MIL-101-PPh3 catalyst exhibited excellent activity and resistance to deactivation.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jonathan De Tovar, Franck Rataboul, Laurent Djakovitch
Summary: The study on a series of palladium(II) complexes with bis(NHC) ligands immobilized on TiO2 surface reveals that these complexes evolve to Pd NPs at the TiO2 surface under reaction conditions, releasing Pd species in the liquid phase. The reactivity is enhanced by the in situ generation of Mott-Schottky heterojunctions, leading to new pathways for the design of heterogenized catalysts in reverse-flow reactors.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Applied
Mingyang Gao, Jiamin Wang, Weixiang Shang, Yuchao Chai, Weili Dai, Guangjun Wu, Naijia Guan, Landong Li
Summary: Suzuki-Miyaura cross-coupling reaction is a powerful method to construct carbon-carbon bonds and is widely used in the synthesis of functional organic compounds. In this study, zeolite-encased Pd particles (Pd@MFI) were successfully prepared and investigated as promising heterogeneous catalysts for the Suzuki-Miyaura cross-coupling reaction. The Pd@MFI catalysts showed high activity, with dispersed Pd particles efficiently stabilized within the MFI zeolite matrix. The presence of basic sites adjacent to Pd sites was crucial for achieving high catalytic activity.
Article
Chemistry, Multidisciplinary
Shiguang Pan, Cong Gao, Jiatong Gui, Beibei Hu, Lifeng Gai, Changsheng Qiao, Chengwei Liu
Summary: A hierarchical titanium dioxide microspheres-supported palladium catalyst (Pd/TiO2-350) was successfully prepared and characterized. The Pd immobilization on TiO2 was confirmed with a palladium loading of 0.1 mmol g(-1) by ICP-OES analysis. Pd/TiO2-350 efficiently catalyzed the Suzuki-Miyaura reaction and could be reused multiple times without significant loss of activity, with a decreased loading of palladium species to 0.001 mol% and high turnover number and turnover frequency of 99,000 and 0.57 s(-1), respectively.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Xiao-Jing Wei, Bingxiang Xue, Jens Handelmann, Zhiyong Hu, Heidar Darmandeh, Viktoria H. Gessner, Lukas J. Goossen
Summary: In this study, a novel catalyst prYPhos was developed to promote Pd-catalyzed Suzuki-Miyaura couplings. Under mild reaction conditions, this catalyst efficiently produced various (hetero)biaryls with good tolerance towards sensitive functional groups and steric hindrance. The results demonstrated that this catalyst exhibited high selectivity in selectively coupling chlorides and leaving triflate groups intact.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Wen-Xin Li, Bo-Wen Yang, Xuan Ying, Zhuo-Wen Zhang, Xue-Qiang Chu, Xiaocong Zhou, Mengtao Ma, Zhi-Liang Shen
Summary: The direct cross-coupling of diaryl sulfoxides with aryl bromides via C-S bond cleavage was achieved using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF. This reaction showed a wide range of substrates and could be used for gram-scale synthesis. The one-pot reaction is operationally simple and economically efficient.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chensen Li, Alastair K. Harrison, Yuchao Liu, Zhennan Zhao, Cheng Zeng, Fernando B. Dias, Zhongjie Ren, Shouke Yan, Martin R. Bryce
Summary: The mechanism of thermally activated delayed fluorescence (TADF) in dendrimers is not clear. This study focuses on fully-conjugated or fully-nonconjugated structures and their impact on TADF efficiency. The researchers synthesized asymmetrical half-dendronized and half-dendronized-half-encapsulated emitters to eliminate degenerate excited states and enhance the spin-flip process. By utilizing a encapsulating tricarbazole unit, nonradiative decay is reduced and TADF performance is improved. The non-doped solution-processed devices achieved high external quantum efficiency (EQE) with low efficiency roll-off at different brightness levels.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Ziwei Wang, Lijuan Li, Weijin Wang, Runlin Wang, Guangzhe Li, Hang Bian, Dongxia Zhu, Martin R. R. Bryce
Summary: In this study, cyclometalated Ir(iii) complexes were designed and synthesized, and were successfully assembled into nanoparticles. These nanoparticles exhibit long wavelength absorption and near-infrared emission, overcoming the limitation of strong absorption in the UV-vis region. Moreover, the nanoparticles show good biocompatibility, high O-1(2) generation ability, potent cytotoxicity towards cancer cells, and superior cellular uptake. This work expands the potential applications of transition metal complex photosensitizers in clinical settings.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Iain A. A. Wright, Marc K. K. Etherington, Andrei S. S. Batsanov, Andrew P. P. Monkman, Martin R. R. Bryce
Summary: Heterocyclic dimers composed of butterfly-shaped phenothiazine and its oxidized form have been synthesized and studied. The presence of certain substituents induces a twist in the dimers. Various analytical techniques, including X-ray crystallography and optical spectroscopy, have been used to understand the relationship between oxidation state, conformational restriction, and emission mechanisms. The mixed dimer exhibits both thermally activated delayed fluorescence and room temperature phosphorescence.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Liping Zhang, Ya-chao Wang, Yuqi Liao, Qian Zhang, Xia Liu, Dongxia Zhu, Haixing Feng, Martin R. Bryce, Lijie Ren
Summary: This study presents a novel approach for the treatment of ischemic stroke using BDP-4/Cur-CL nanoparticles. These nanoparticles can release visible light signals for real-time monitoring of the progression of ischemia reperfusion brain injury, while also releasing curcumin for safe treatment. The experimental results demonstrate excellent anti-apoptotic and anti-inflammatory effects of this method, effectively improving the cognitive abilities of stroke mice.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Summary: This review provides a comprehensive summary of the applications of aggregation-induced emission (AIE) luminogens in biological imaging, dynamic physiological processes, disease diagnosis and treatment, and specific analyte detection and monitoring. The review also discusses critical issues and future directions, aiming to promote the development of AIE in the fields of life and health.
Article
Chemistry, Inorganic & Nuclear
Ahmed M'hamedi, Andrei S. Batsanov, Mark A. Fox, Juan A. Aguilar, Martin R. Bryce
Summary: Six new diiridium complexes with 2-methyl-6-phenylpyridyl as the cyclometalating ligand and mu(2)-oxamidato or mu(2)-dithioxamidato as the bridging ligand have been synthesized. The presence of multiple isomers in these complexes was confirmed by NMR and X-ray crystallography, and computational calculations supported the experimental findings. The emission spectra of these complexes were attributed to mixed metal-ligand to ligand charge transfer excited states.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Rebecca J. Salthouse, Juan Hurtado-Gallego, Iain M. Grace, Ross Davidson, Ohud Alshammari, Nicolas Agrait, Colin J. Lambert, Martin R. Bryce
Summary: We studied a series of thiomethyl anchored cross-conjugated molecules and their skipped-conjugated alcohol derivatives using experimental and theoretical methods. The conductance values of the cross-conjugated molecules and their skipped-conjugated partners were found to be similar. Theoretical studies revealed that the conductance of the alcohol series of compounds varied more with the tilt angle. Thermopower measurements showed that the cross-conjugated ketone molecules had a higher Seebeck coefficient compared to the alcohol derivatives, with a particularly high value for the biphenyl derivative 3a.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Polymer Science
Nan Jiang, Ke-Xin Li, Wei Xie, Shu-Ran Zhang, Xin Li, Yue Hu, Yan-Hong Xu, Xing-Man Liu, Martin R. Bryce
Summary: In this study, clusters with different extents of aggregation were successfully prepared by heat-induced or light-triggered methods, and the multicolor fluorescence of a single polymeric material was controllably regulated. The luminescence behavior of the material varied with the microscopic control of the aggregation structure. This research provides a template for developing new materials for multicolor fluorescence and demonstrates the potential of PUE as a smart material through the construction of a pattern with encryption, anticounterfeiting, and information transmission functions.
Article
Multidisciplinary Sciences
Andrea Gemma, Fatemeh Tabatabaei, Ute Drechsler, Anel Zulji, Herve Dekkiche, Nico Mosso, Thomas Niehaus, Martin R. Bryce, Samy Merabia, Bernd Gotsmann
Summary: By combining the break junction technique with a suspended heat-flux sensor, the researchers measured the total thermal and electrical conductance of a single molecule, at room temperature, along with its Seebeck coefficient. The result is in agreement with predictions and opens new opportunities for thermoelectric applications.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Saliha Oner, Martin R. R. Bryce
Summary: This review focuses on the fused-ring carbazole derivatives, their design, properties, and applications in OLEDs. The appeal of these materials lies in their extended π-electron systems, thermal stability, tunable orbital energies, high photoluminescence quantum yields, and versatility for chemical functionalisation. The review is divided into sections based on the molecules' roles in OLEDs, including conventional emitters, hosts for phosphorescent emitters, TADF emitters, and MR emitters. The challenges and opportunities for these derivatives in OLEDs and other optoelectronic applications are also discussed.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Luke J. O'Driscoll, Michael Jay, Benjamin J. Robinson, Hatef Sadeghi, Xintai Wang, Becky Penhale-Jones, Martin R. Bryce, Colin J. Lambert
Summary: The synthesis of alkanethiol molecules with planar aromatic head groups for anchoring molecules to graphene electrodes is investigated. The conductance of self-assembled monolayers on a gold surface shows that graphene coated probes have higher conductance than platinum probes. The study confirms the effectiveness of planar aromatic head groups as anchoring units, but highlights the importance of considering the size and geometry of these groups for molecular design.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Nan Jiang, Ke-Xin Li, Jia-Jun Wang, Chen-Sen Li, Xiao-Yu Xu, Yan-Hong Xu, Martin R. Bryce
Summary: This article presents the achievement of cluster-induced aggregation, multicolour luminescence, and ultra-long phosphorescence in non-conjugated luminescent polymers (NCLPs) based on linear polyurethane derivatives. By adjusting the reaction temperature and time, the authors successfully prepared NCLPs with ultra-long room temperature phosphorescence lifetime of 0.45 s. DFT calculations and molecular dynamics simulations provided detailed microstructural information on the polyurethane derivatives, revealing the underlying luminous mechanism. The potential of the polyurethane derivatives in information security was validated through experimental encryption/decryption models. These findings have important implications for understanding unconventional luminescence mechanisms and strategic design of NCLPs for practical applications.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Review
Chemistry, Multidisciplinary
Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Summary: This review provides a comprehensive summary of the advantages and applications of aggregation-induced emission (AIE) luminogens in imaging of biological structure, dynamic physiological processes, disease diagnosis and treatment, as well as detection and monitoring of specific analytes. It also discusses future directions to promote research and development in the fields of life and health.
Article
Chemistry, Physical
Xintai Wang, Ali Ismael, Shanglong Ning, Hanan Althobaiti, Alaa Al-Jobory, Jan Girovsky, Hippolyte P. A. G. Astier, Luke J. O'Driscoll, Martin R. Bryce, Colin J. Lambert, Christopher J. B. Ford
Summary: This study investigates the effect of the molecule-electrode interface in SAMs using a micro-pore device, overcoming challenges with the tetrapodal anchor and single layered graphene top electrode with an ionic liquid gate. Experimental results show that molecules with the same backbone but different molecule-electrode interfaces exhibit significantly different conductances near zero bias.
NANOSCALE HORIZONS
(2022)
Article
Chemistry, Physical
Juan Hurtado-Gallego, Ross Davidson, Iain M. Grace, Laura Rincon-Garcia, Andrei S. Batsanov, Martin R. Bryce, Colin J. Lambert, Nicolas Agrait
Summary: This study presents a combined experimental and computational investigation on seven cross-conjugated enediyne derivatives. The results demonstrate the presence of multiple conductance plateaus in gold|single-molecule|gold junctions for most of the molecules, and the underlying mechanisms are explained using experimental and theoretical data.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
