Review
Engineering, Chemical
Yin Zhu, Meijin Lu, Feng Gao, Chunli Zhou, Chenyang Jia, Jingtao Wang
Summary: This paper systematically summarizes the role of tailor-made additives (TMAs) in solution crystallization. It discusses the effects and action mechanisms of TMAs on crystal nucleation and growth, introduces the applications of TMAs in regulating crystal properties, and discusses the recent progress of molecular simulation in predicting the role of TMAs. It also analyzes the existing problems in this field and provides an outlook on future development. This paper is helpful and useful to readers interested in the use of TMAs to control crystallization and design crystals with desired properties.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xichong Ye, Zhaoxu Wang, Jie Zhang, Xinhua Wan
Summary: A strategy using commercially available achiral polymers as platforms and attaching various chiral small molecules as recognition side-chains through non-covalent interactions was reported. This method was used to selectively crystallize seven racemates in different solvents, showing good stereoselectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Materials Science, Multidisciplinary
Hengyu Zhou, Julia Sabino, Yongfan Yang, Michael D. Ward, Alexander G. Shtukenberg, Bart Kahr
Summary: Tailor-made additives (TMAs) play a role in crystal morphology engineering by binding to crystal surfaces through stereochemical recognition. This review focuses on the use of TMAs in influencing crystal growth during cooling of melts. The key difference between growth from solutions and growth from melts lies in the thermodynamic parameters of solute supersaturation and undercooling. TMAs can effectively influence the growth kinetics, crystal morphology, nucleation, surface recognition, and polarity determination of crystals in both scenarios, but may require new optical tools to understand their influence under high supercooling conditions.
ANNUAL REVIEW OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Peter L. Kaskiewicz, Ian Rosbottom, Robert B. Hammond, Nicholas J. Warren, Colin Morton, Peter J. Dowding, Neil George, Kevin J. Roberts
Summary: A workflow combining molecular modeling and experimental techniques is used to tailor additive screening and crystallization control, focusing on the impact of carboxylic acid-containing additives on nucleation of a target compound. Tailor-made additives with stronger carboxylic group dimer interactions with the compound are found to stabilize dimers in solution and influence nucleation pathways. Experimental results demonstrate the ability of tailor-made additives to change the nucleation mechanism and increase effective interfacial tension.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Henryk Janeczek, Khadar Duale, Wanda Sikorska, Marcin Godzierz, Aleksandra Kordyka, Andrzej Marcinkowski, Anna Hercog, Marta Musiol, Marek Kowalczuk, Darinka Christova, Joanna Rydz
Summary: This paper investigates the liquid crystal properties of poly(L-lactide) (PLLA) and demonstrates the ability of pressed PLLA films to self-assemble into different mesophases under mechanical pressure, temperature, and time. The research shows that these films have a wide temperature stability range and can persist for years at ambient temperature. This opens up new prospects for advanced photonic green applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Polymer Science
Pin Hu, Anil Kumar, Reza Gharibi, Seema Agarwal
Summary: The study developed fast-degrading polyurethanes by introducing degradable ester units through a polyaddition reaction, showing high mechanical strength and almost complete degradation in 3 months at 45 degrees Celsius, significantly faster than known compostable polymers.
Article
Engineering, Chemical
Maya Khellaf, Xiaoqian Huang, Jean-Pierre Valour, Denis Mangin, Catherine Charcosset, Elodie Chabanon Lyon
Summary: Crystallization is a crucial unit operation driven by supersaturation in process industries. Membrane pervaporation, utilizing selective evaporation, can control phase transition and polymorphism. This study investigates the crystallization of L-glutamic acid using a semi-continuous system with HybSi (R) membranes, analyzing the influence of operating parameters on solvent separation, solute crystallization, and polymorphism control. The results validate the concept and reveal the preferential crystallization of one polymorphic form. However, concentration polarization and fouling decrease process performance due to local supersaturation and cooling during pervaporation.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Chemistry, Physical
Domenico Pirozzi, Michele Pansini, Antonello Marocco, Serena Esposito, Gabriele Barrera, Paola Tiberto, Paolo Allia, Filomena Sannino
Summary: In recent years, gallic acid (GA) has been widely used in various industrial applications due to its unique properties. However, the presence of GA in wastewater poses significant environmental challenges. In order to address this issue, two custom-made magnetic metal-ceramic nanocomposites were developed from zeolite A to selectively adsorb GA from wastewater. The optimization of the nanocomposites' configuration, aiming to enhance adsorption capacity and stability, was achieved through modifications of a patented process. The adsorption process was characterized by investigating key parameters such as kinetics, pH, and GA concentration. The results revealed that the adsorption of GA was strongly influenced by pH, and interactions between GA and the nanocomposites occurred through two distinct mechanisms. The adsorption kinetics followed a pseudo second-order model, while the adsorption isotherms data were well described by the Sips model, which combines the Langmuir and Freundlich isotherm models. Conditions for GA desorption and magnetic adsorbent recycling were also identified. Additionally, a thermal regeneration procedure for the exhausted adsorbent was developed based on thermogravimetric (TG) and differential thermal analysis (DTA). Furthermore, an alkaline desorption procedure was successfully developed to facilitate a more environmentally friendly approach and ensure the complete recovery of economically valuable GA. A detailed cost analysis demonstrated that the specific cost for removing GA per unit volume is comparable to alternative methods.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Jiaojun Tan, Shaowei Ruan, Meiyun Zhang, Hui He, Shunxi Song, Bin Yang, Jingyi Nie, Qiuyu Zhang
Summary: This study reports a method to transform cellulosic biomass into stabilizers for nonaqueous emulsions by decorating with alkyl chains. It is found that the length of the alkyl chains significantly influences the stability and type of the emulsions, which exhibit long-term stability. Water-sensitive interfacial polymerizations are successfully performed using these nonaqueous emulsions, producing capsules and particles.
Article
Chemistry, Multidisciplinary
Mengyi Li, Yueyuan Ma, Xu Zhang, Lizhan Zhang, Xinyu Chen, Jian-Wen Ye, Guo-Qiang Chen
Summary: This study successfully reprogrammed Pseudomonas entomophila to synthesize PHA copolymers with both short- and medium/long-chain-length monomers. By optimizing the synthesis pathways, novel copolymers with high PHB content were produced, providing a new approach for the synthesis of tailor-made PHA polymers.
ADVANCED MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Sreejan Manna, Sougata Jana
Summary: Marine polysaccharides have attracted interest as biomaterials for drug delivery applications due to their low cytotoxicity and potential health benefits. This review provides an overview of marine polysaccharides, their classification based on biological sources, and their applications in tissue-specific drug delivery.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Environmental Sciences
Merve Atasoy, Zeynep Cetecioglu
Summary: This study successfully increased propionic acid production efficiency by bioaugmenting Propionibacterium acidipropionici. However, there was no significant difference in VFA composition, demonstrating the feasibility of this strategy.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Biochemistry & Molecular Biology
Punlop Kuntiyong, Duangkamon Namborisut, Kunita Phakdeeyothin, Rungrawin Chatpreecha, Kittisak Thammapichai
Summary: Benzoquinolizidinone systems were synthesized in both enantiomeric forms from L-glutamic acid by the key chiral arylethylglutarimide intermediate. The synthesis involved aldol reaction, regioselective hydride reduction, N-acyliminium ion cyclization, and Cope elimination to convert diastereomers into enantiomers.
Article
Chemistry, Multidisciplinary
M. K. Singh, Arup Banerjee
Summary: This study computationally examined the impact of various additives on the asymmetry of a-resorcinol crystal growth in different solutions, revealing that the growth rate of oxygen-rich faces is faster in water and acetone solutions but slower in acetic acid-mediated crystallization. Asymmetry in growth decreases with increasing saturation temperatures and supersaturation, with acetic acid inducing higher asymmetry on oxygen-rich faces compared to hydrogen-rich faces.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Justus Kuemper, Jerome Meyers, Rebecca Sebers, Nils Kurig, Regina Palkovits
Summary: Acrylonitrile is an important industrial chemical produced by the SOHIO process using fossil resources. To achieve sustainable production, a new route using biogenic substrates and electrolysis is proposed. The electrochemical synthesis of green acrylonitrile using d,l-glutamic acid as a substrate is achieved through electro-oxidative decarboxylation and non-Kolbe electrolysis, resulting in a two-step process with a maximum yield of 41.1%.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
