Article
Biochemistry & Molecular Biology
Mounir Raji, Tam Minh Le, Thu Huynh, Andras Szekeres, Viktoria Nagy, Istvan Zupko, Zsolt Szakonyi
Summary: A series of novel diaminopyrimidines containing pinane moieties were synthesized efficiently. Compound 18a exhibited strong antiproliferative activities against four human cancer cell lines, while compound 22a selectively inhibited the proliferation of HeLa cells. Furthermore, compounds 12b and 17a showed selective inhibition against Gram-positive bacteria.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Organic
Ya-Li Wu, Min Jiang, Li Rao, Ying Cheng, Wen-Jing Xiao, Jia-Rong Chen
Summary: A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This reaction utilizes N-aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to 1,2-aminoalkoxylation products with high yields and regioselectivity.
Review
Chemistry, Organic
Brett N. Hemric
Summary: 1,2-Amino oxygenation is an important synthetic strategy for the synthesis of pharmaceuticals, natural products, and synthetic ligands, with a wide range of applications. Modern chemistry has developed a variety of novel methods for 1,2-amino oxygenation, such as using different transition metals and electrochemical, photochemical, and biochemical reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Analytical
Seyedeh Faezeh Taghizadeh, Mahsa Naseri, Hamid Ahmadpourmir, Majid Azizi, Ramin Rezaee, Gholamreza Karimi
Summary: This study analyzed the levels of 3-MCPD and 1,3-DCP in 45 edible vegetable oil samples from the Iran market. The results showed significant differences in the average concentrations of 3-MCPD and 1,3-DCP among different types of vegetable oils, but no significant differences among different brands. Sesame and corn oils had the highest and lowest average concentrations of 3-MCPD and 1,3-DCP, respectively. The calculated Hazard Index values indicated no major risk to Iranian consumers. However, it is necessary to understand the processes leading to the formation of these contaminants, develop real-time monitoring methods, and mitigate the occurrence of such chemicals while ensuring food safety and sensory properties.
MICROCHEMICAL JOURNAL
(2023)
Review
Food Science & Technology
Yajing Xie, H. J. van der Fels-klerx, Stefan P. J. van Leeuwen, Vincenzo Fogliano
Summary: Infant formula may contain thermal processing contaminants such as dAGEs, GEs, MCPDEs, depending on the formulation and processing conditions. Hydrolyzed protein formulations can promote dAGEs formation, while different carbohydrates in recipes lead to varying glycation extents.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Chemistry, Organic
Arianna Brandolese, Mark D. Greenhalgh, Titouan Desrues, Xueyang Liu, Shen Qu, Cyril Bressy, Andrew D. Smith
Summary: This study demonstrates the sequential acylative kinetic resolution of C-2-symmetric (+/-)-1,2-syn and (+/-)-1,3-anti-diols using a packed bed microreactor loaded with HyperBTM in flow. Each substrate class showed significant differences in relative rate constants for each KR process. Optimization of the flow system allowed for isolation of reaction products in high enantiopurity and yield.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sarita Katiyar, Abhishek Kumar, Koneni Sashidhara
Summary: A silver-catalyzed decarboxylative cyclization process has been developed to synthesize substituted pyrazoles from readily available 1,2-diaza-1,3-dienes and alpha-keto acids. Under optimized conditions, a series of multisubstituted pyrazoles were synthesized in moderate to good yields. Furthermore, the synthetic utility of this method has been demonstrated by synthesizing analogs of FDA approved drugs such as anti-inflammatory drug, lonazolac and antiobesity drug, rimonabant.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jian Song, Wen-Hua Zheng
Summary: A highly enantioselective kinetic resolution of racemic 1,3-amino alcohols via O-Acylation was achieved using a chiral organotin catalyst. The reaction showed excellent efficiency and high enantioselectivity, with better selectivity for anti-1,3-amino alcohols.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Jia Wang, Joshua H. Marks, Andrew M. Turner, Anatoliy A. Nikolayev, Valeriy Azyazov, Alexander M. Mebel, Ralf Kaiser
Summary: The formation pathways of hydroxyacetone, methyl acetate, and 3-hydroxypropanal, as well as their enol tautomers, within mixed ices analogous to interstellar ices have been unraveled for the first time. This study provides insights into the formation mechanisms of these molecules and suggests potential candidates for future astronomical searches.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Ahlem Eddehech, Renaud Rahier, Nabil Smichi, Yani Arhab, Alexandre Noiriel, Abdelkarim Abousalham, Adel Sayari, Zied Zarai
Summary: The recombinant Serratia sp. W3 lipase (rSmL) expressed in E. coli showed significantly higher specific activity compared to the native lipase (nSmL) when using olive oil as the substrate. Both rSmL and nSmL were capable of hydrolyzing ester bonds at sn-1 and sn-3 positions, however, exhibited a clear preference towards the sn-3 position of certain triglycerides due to steric hindrance within the enzyme's catalytic pocket.
PROCESS BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Keita Komine, Riki Ninomiya, Hayato Fukuda, Jun Ishihara
Summary: This paper describes the desymmetrization of a meso-cyclic 1,3-dione pinacol coupling using samarium diiodide (SmI2). The reaction exhibits high stereoselectivity, resulting in fused carbocyclic compounds with three contiguous stereogenic centers, including an all-carbon quaternary center and a cis-1,2-diol moiety.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Nanoscience & Nanotechnology
Abhishek Dubey, Dae Won Park, Jung Eun Kwon, Yong Joon Jeong, Taegeun Kim, Inhye Kim, Se Chan Kang, Ki-Whan Chi
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Article
Chemistry, Inorganic & Nuclear
Abhishek Dubey, Yong Joon Jeong, Jae Ho Jo, Sangkook Woo, Dong Hwan Kim, Hyunuk Kim, Se Chan Kang, Peter J. Stang, Ki-Whan Chi
Article
Chemistry, Physical
Abhishek Dubey, Eugene Khaskin
Article
Chemistry, Physical
Abhishek Dubey, Luca Nencini, Robert R. Fayzullin, Carlo Nervi, Julia R. Khusnutdinova
Article
Chemistry, Multidisciplinary
Anurag Mishra, Abhishek Dubey, Jin Wook Min, Hyunuk Kim, Peter J. Stang, Ki-Whan Chi
CHEMICAL COMMUNICATIONS
(2014)
Article
Chemistry, Multidisciplinary
Abhishek Dubey, Jin Wook Min, Hyun Jung Koo, Hyunuk Kim, Timothy R. Cook, Se Chan Kang, Peter J. Stang, Ki-Whan Chi
CHEMISTRY-A EUROPEAN JOURNAL
(2013)
Review
Chemistry, Multidisciplinary
Hyunji Jung, Abhishek Dubey, Hyun Jung Koo, Vaishali Vajpayee, Timothy R. Cook, Hyunuk Kim, Se Chan Kang, Peter J. Stang, Ki-Whan Chi
CHEMISTRY-A EUROPEAN JOURNAL
(2013)
Article
Chemistry, Inorganic & Nuclear
Abhishek Dubey, Anurag Mishra, Jin Wook Min, Min Hyung Lee, Hyunuk Kim, Peter J. Stang, Ki-Whan Chi
INORGANICA CHIMICA ACTA
(2014)
Article
Chemistry, Organic
Pradeep Kumar, Abhishek Dubey, Anand Harbindu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2012)
Article
Chemistry, Inorganic & Nuclear
Vaishali Vajpayee, Sun Mi Lee, Joeng Woo Park, Abhishek Dubey, Hyunuk Kim, Timothy R. Cook, Peter J. Stang, Ki-Whan Chi
Article
Chemistry, Organic
Abhishek Dubey, Anand Harbindu, Pradeep Kumar
SYNTHESIS-STUTTGART
(2011)
Article
Chemistry, Physical
Abhishek Dubey, S. M. Wahidur Rahaman, Robert R. Fayzullin, Julia R. Khusnutdinova
Article
Chemistry, Physical
S. M. Wahidur Rahaman, Dilip K. Pandey, Orestes Rivada-Wheelaghan, Abhishek Dubey, Robert R. Fayzullin, Julia R. Khusnutdinova
Meeting Abstract
Chemistry, Multidisciplinary
Eugene Khaskin, Tanner Jankins, Abhishek Dubey, Robert Fayzullin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Abhishek Dubey, Julia Khusnutdinova
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
