Journal
TETRAHEDRON
Volume 65, Issue 2, Pages 461-468Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.11.028
Keywords
Hydrazone; alpha-Diazo ester; Fischer indole synthesis
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Funding
- MEXT. HAITEKU
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Aryl hydrazones, the precursor of Fischer indole synthesis, were easily obtained by nucleophilic addition of aryllithium reagents to diazo esters. The aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol. Grignard reagent was also a good nucleophile, whereas organozinc reagent did not react with diazo esters. Aryllithium reagents were prepared by reacting aryl bromides having various substitutions at 2-, 3-. 4-, or multi positions with n-BuLi. The addition of nucleophiles derived from bromopyridines to diazo esters also gave hydrazones. (C) 2008 Elsevier Ltd. All rights reserved.
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