Article
Chemistry, Multidisciplinary
Qing Li, Yinrui Shi, Yina Ma, Liuyang Ding, Xiang Li, Jiuling Li, Yafei Guo, Baomin Fan
Summary: In this study, a new catalytic strategy for the synthesis of α-tertiary primary amines from commercial nitriles is reported. The method involves the addition of organolithium reagents to nitriles to generate imine intermediates, followed by copper catalyzed enantioselective addition of AllylBpin to form the final amines. This strategy offers high yields (up to 90%) and excellent enantiomeric excess (95%).
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Wongyu Lee, Dongwook Kim, Sangwon Seo, Sukbok Chang
Summary: In this study, a polar-radical relay strategy is reported for the alpha-C-H amination of cyclic amines using N-chloro-N-sodio-carbamates. The strategy involves the in situ generation of a cyclic iminium intermediate using N-iodosuccinimide (NIS) as an oxidant, followed by a series of polar and radical reactions to achieve controlled C-N bond formation. The method provides a facile and regioselective access to a broad range of alpha-amino cyclic amines and demonstrates excellent applicability for functionalization of biologically relevant compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Yaru Gao, Guorong Hong, Bin-Miao Yang, Yu Zhao
Summary: Direct substitution of readily available alcohols is an important area of research in green chemical synthesis. Catalytic enantioconvergent transformations of racemic secondary alcohols are desired for efficient access to valuable enantiopure compounds. The enantioconvergent borrowing hydrogen methodology has proven to be effective for achieving such transformations. This review provides an overview of the progress made in the past decade, focusing on the conversion of racemic secondary alcohols to enantioenriched chiral amines, N-heterocycles, higher-order alcohols, and ketones.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yang Yuan, Fengqian Zhao, Xiao-Feng Wu
Summary: This study introduces a copper-catalyzed enantioselective hydroaminocarbonylation method for constructing alpha-chiral secondary amides. The method shows high yields and high levels of enantioselectivity under very mild conditions. Additionally, alpha,beta-Unsaturated secondary amides can be produced by using alkynes as the substrate.
Article
Chemistry, Organic
Yuma Kurose, Kazuhiro Okamoto, Yohei Okada, Yoshikazu Kitano, Kazuhiro Chiba
Summary: Ring oxygen-substituted artificial nucleosides, with furanose structure, exhibit unique pharmacological activities as anticancer and antiviral agents, even when not incorporated into oligonucleotides. Direct anodic N-alpha hydroxylation in aqueous media is demonstrated as a practical synthetic method for versatile intermediates in the preparation of azanucleoside derivatives.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rebecca A. Kehner, Ge Zhang, Liela Bayeh-Romero
Summary: A mild and catalytic method for the semireduction of both secondary and tertiary amides via zirconocene hydride catalysis is reported. The reduction of secondary amides gives a diverse array of imines in up to 94% yield with excellent chemoselectivity using just 5 mol % of Cp2ZrCl2, without the need for glovebox handling. Furthermore, a novel reductive transamination of tertiary amides is achieved in the presence of a primary amine at room temperature, providing access to an expanded assortment of imines in up to 98% yield. Through slight procedural tuning, the single-flask conversion of amides to imines, aldehydes, amines or enamines is feasible, including multicomponent syntheses.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Ceramics
G. Gutierrez, M. Bricout, F. Garrido, A. Debelle, L. Roux, C. Onofri
Summary: It was found that electronic energy dissipation has a significant acceleration effect on the formation and evolution of defects induced by nuclear energy deposition, and the magnitude of this acceleration depends on both the electronic energy loss level and the microstructure at the moment when the coupling occurs.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Organic
Sho Amemiya, Shingo Okemoto, Akira Tsubouchi, Akio Saito
Summary: A synthetic method for alpha-(aminoethyl)-alpha,beta-enones from aryl-substituted homopropargyl sulfonamides and aldehydes was developed, representing the first synthesis of conjugated enones via alkyne aza-Prins cyclization. These products could be further converted into pyrrolidines.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Yan He, Qimeng Liu, Zihe Du, Yanhua Xu, Lingyu Cao, Xinying Zhang, Xuesen Fan
Summary: A strategy for a,fi-difunctionalization and C-N bond cleavage of saturated amines with benzo[c]isoxazoles was disclosed, involving B(C6F5)3-catalyzed consecutive hydrogen-borrowing and [4 + 2] cycloaddition followed by a C-N bond cleavage process. The reactions proceed efficiently without the need for oxidants and metal catalysts, providing a broad range of quinoline derivatives in an atom-economical manner.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jagannath Rana, Palaniyappan Nagarasu, Murugan Subaramanian, Akash Mondal, Vedichi Madhu, Ekambaram Balaraman
Summary: The general and efficient C(alpha)-alkylation of oxindoles with unactivated secondary alcohols as alkylating agents catalyzed by a newly developed NNN-Mn(II) complex demonstrates the importance of the NH moiety in the complex and M-L cooperation during the catalytic transformation.
Article
Chemistry, Organic
Esteban E. Bjerg, Joaquin Marchan-Garcia, Eduardo Buxaderas, Yanina Moglie, Gabriel Radivoy
Summary: The oxidative alpha-functionalization of 2-aryl-1,2,3,4tetrahydroisoquinolines (THIQs) has been achieved using a versatile heterogeneous nanocatalyst composed of copper nanoparticles immobilized on silica-coated maghemite. The catalyst showed high efficiency in cross-dehydrogenative coupling reactions and alpha-oxidation reactions. It can be easily recovered and reused without significant loss of activity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Przemyslaw Zareba, Anna K. Drabczyk, Sylwia Wnorowska, Artur Wnorowski, Jolanta Jaskowska
Summary: According to the World Health Organization, infectious diseases continue to pose a significant threat to public health. Due to factors such as antibiotic resistance, immunopressure, and genetic mutations, there is a need to search for new molecules with antimicrobial and antiviral activities. This study investigated the antimicrobial and antiviral properties of compounds from the cyclic arylguanidine group, with promising results.
BIOORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Miao Jia, Lixin Zhang, Qiong Yuan
Summary: This article summarizes the application and research progress of COF anode materials in lithium-ion batteries, sodium-ion batteries, and potassium-ion batteries in recent years, starting from the functional group structure, type, and number of active sites of COF materials. It discusses the energy storage mechanism of COF materials and expounds the application prospects of COF electrodes in the field of energy storage.
Article
Chemistry, Physical
Kyung Min Kim, Geon-il Kim, Gyeong-Ho Son, Yun-Ha Yoo, Sujik Hong, Jung-Gu Kim
Summary: The automobile industry often uses cyclic corrosion tests (CCTs) to assess material durability. However, the lengthy evaluation period of CCTs can be problematic in this fast-paced industry. To overcome this challenge, researchers have explored a new approach that combines a CCT with an electrochemically accelerated corrosion test to reduce the evaluation time. This method involves the formation of a corrosion product layer through a CCT, resulting in localized corrosion, followed by an electrochemically accelerated corrosion test using an agar gel electrolyte to preserve the corrosion product layer. The results demonstrate that this approach can achieve comparable localized corrosion resistance, with similar area ratios and depths, in half the time compared to a conventional CCT.
Article
Chemistry, Applied
Xuefeng Jia, Jieting He
Summary: In this study, three copper complexes were synthesized and used in the construction of C-N bonds. Among them, complex II displayed higher activity in the reaction compared to the other two complexes. The reaction showed advantages such as a wide scope of substrates, high yields, and mild reaction conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Genetics & Heredity
D. Gareth Evans, Siva Sithambaram, Elke Maria van Veen, George J. Burghel, Helene Schlecht, Elaine F. Harkness, Helen Byers, Jamie M. Ellingford, Ashu Gandhi, Sacha J. Howell, Anthony Howell, Claire Forde, Fiona Lalloo, William G. Newman, Miriam Jane Smith, Emma Roisin Woodward
Summary: This study aimed to investigate the frequency of germline pathogenic variants (PVs) in women with ductal carcinoma in situ (DCIS) and grade 1 invasive breast cancer (G1BC). The results showed that DCIS was more likely to be associated with both BRCA1/2 and non-BRCA1/2 PVs than G1BC. Extended panel testing is recommended for young-onset DCIS where PV detection rates are highest.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Oncology
D. Gareth Evans, Emma R. Woodward
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jose Garcia-Pelaez, Rita Barbosa-Matos, Silvana Lobo, Alexandre Dias, Luzia Garrido, Sergio Castedo, Sonia Sousa, Hugo Pinheiro, Liliana Sousa, Rita Monteiro, Joaquin J. Maqueda, Susana Fernandes, Fatima Carneiro, Nadia Pinto, Carolina Lemos, Carla Pinto, Manuel R. Teixeira, Stefan Aretz, Svetlana Bajalica-Lagercrantz, Judith Balmana, Ana Blatnik, Patrick R. Benusiglio, Maud Blanluet, Vincent Bours, Hilde Brems, Joan Brunet, Daniele Calistri, Gabriel Capella, Sergio Carrera, Chrystelle Colas, Karin Dahan, Robin de Putter, Camille Desseignes, Elena Dominguez-Garrido, Conceicao Egas, D. Gareth Evans, Damien Feret, Eleanor Fewings, Rebecca C. Fitzgerald, Florence Coulet, Maria Garcia-Barcina, Maurizio Genuardi, Lisa Golmard, Karl Hackmann, Helen Hanson, Elke Holinski-Feder, Robert Huneburg, Mateja Krajc, Kristina Lagerstedt-Robinson, Conxi Lazaro, Marjolijn J. L. Ligtenberg, Cristina Martinez-Bouzas, Sonia Merino, Genevieve Michils, Srdjan Novakovic, Ana Patino-Garcia, Guglielmina Nadia Ranzani, Evelin Schrock, Ines Silva, Catarina Silveira, Jose L. Soto, Isabel Spier, Verena Steinke-Lange, Gianluca Tedaldi, Maria-Isabel Tejada, Emma R. Woodward, Marc Tischkowitz, Nicoline Hoogerbrugge, Carla Oliveira
Summary: This study analyzed families carrying rare CDH1 variants, comparing the cancer spectrum in carriers of pathogenic or likely pathogenic variants (PV/LPV) or missense variants of unknown significance, and evaluated the performance of expanded criteria for CDH1 testing. The results showed that PV/LPV carriers were positively associated with lobular breast cancer, diffuse gastric cancer, and gastric cancer, while missense variants of unknown significance did not show this positive association.
Review
Medicine, General & Internal
Charlotte Carton, D. Gareth Evans, Ignacio Blanco, Reinhard E. Friedrich, Rosalie E. Ferner, Said Farschtschi, Hector Salvador, Amedeo A. Azizi, Victor Mautner, Claas Roehl, Sirkku Peltonen, Stavros Stivaros, Eric Legius, Rianne Oostenbrink
Summary: This study aims to integrate information on NF1-associated tumors to assist healthcare professionals in tumor surveillance of NF1 individuals. Personalized and targeted tumor management proposals have been defined to ensure appropriate care for those in need.
Review
Obstetrics & Gynecology
Denise R. Nebgen, Susan M. Domchek, Joanne Kotsopoulos, Joanne A. de Hullu, Emma J. Crosbie, Vincent Singh Paramanandam, Monique Brood van Zanten, Barbara M. Norquist, Theresa Guise, Serge Rozenberg, Allison W. Kurian, Holly J. Pederson, Nese Yuksel, Rachel Michaelson-Cohen, Sharon L. Bober, Agnaldo Lopes da Silva, Nora Johansen, F. Guidozzi, D. Gareth Evans, Usha Menon, Sheryl A. Kingsberg, C. Bethan Powell, Giovanni Grandi, Claudia Marchetti, Michelle Jacobson, Donal J. Brennan, Martha Hickey
Summary: Women with high inherited risk of ovarian cancer can undergo risk-reducing salpingo-oophorectomy (RRSO) between the ages of 35 and 45. While RRSO can save lives, it can also cause symptoms that negatively impact quality of life and long-term health. This scoping review explores the effects of RRSO on short- and long-term health and provides evidence-based international consensus recommendations for comprehensive care.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Michelle Harvie, David P. French, Mary Pegington, Cheryl Lombardelli, Suzy Krizak, Katharine Sellers, Emma Barrett, D. Gareth Evans, Ramsey Cutress, Andrea Wilding Rgn, Lee Graves, Anthony Howell
Summary: This study compared the efficacy of two remotely delivered weight loss programs and written advice. The results showed that both weight loss programs resulted in more women achieving a weight loss of ≥10%, but there was no evidence of additional benefits from the multiple disease prevention program. Therefore, a multicenter RCT is warranted to test the weight loss program across breast cancer Family History, Risk and Prevention Clinics in the UK.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Robert D. Morgan, Andrew R. Clamp, Bethany M. Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S. Sundar, Shibani Nicum, James D. Brenton, Rebecca S. Kristeleit, Susana Banerjee, Iain A. McNeish, Jonathan A. Ledermann, Stephen S. Taylor, D. Gareth R. Evans, Gordon C. Jayson
Summary: This study reports data from the first year of routine homologous recombination deficiency testing in the NHS in England, Wales, and Northern Ireland, demonstrating the significant survival benefits of olaparib plus bevacizumab maintenance therapy in women with newly diagnosed, advanced, high-grade ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Editorial Material
Genetics & Heredity
Nicola Flaum, Emma J. Crosbie, Emma Roisin Woodward, Fiona Lalloo, Robert Morgan, Neil Ryan, D. Gareth Evans
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Genetics & Heredity
D. Gareth Evans, Elaine F. Harkness, Emma R. Woodward
Summary: Germline TP53 variants, particularly the p.R337H and p.P152L, are associated with different cancer risks in Li-Fraumeni syndrome. The p.P152L variant is mainly linked to childhood adrenal tumors and has lower risks for non-adrenal tumors compared to the p.R337H variant. Understanding codon-specific cancer risks is crucial for individualized risk assessment and prevention strategies in LFS.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steven Squires, Elaine Harkness, Dafydd Gareth Evans, Susan M. Astley
Summary: This study aims to build automated models using deep learning based on the scores given by radiologists to predict mammographic breast density accurately and consistently. The approach involves using pretrained deep networks to generate feature vectors for regression analysis, and the results show that the model performs at a similar level to human experts in estimating cancer risk. The study also demonstrates the high consistency and potential of the model.
JOURNAL OF MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steven Squires, Elaine F. Harkness, D. Gareth Evans, Susan M. Astley
Summary: High breast density is associated with reduced efficacy of mammographic screening and increased breast cancer risk. Accurate automated density estimates can be used for risk prediction. However, expert reader assessments of density show variation and this variability affects the model's mapping from representation to prediction.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Article
Psychology, Clinical
Victoria G. Woof, Lorna McWilliams, Anthony Howell, D. Gareth Evans, David P. French
Summary: This study aimed to gain an in-depth understanding of women's lived experiences of receiving an increased breast cancer risk. The findings suggest that providing risk predictions has little impact on women's beliefs about breast cancer risk, and discussions with healthcare professionals are needed to help women form more accurate appraisals and make informed decisions.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Grace E. Gregory, Adam Paul Jones, Michael J. Haley, Christopher Hoyle, Leo A. H. Zeef, I-Hsuan Lin, David J. Coope, Andrew T. King, D. Gareth Evans, Pawel Paszek, Kevin N. Couper, David Brough, Omar N. Pathmanaban
Summary: Bilateral vestibular schwannoma is a characteristic feature of NF2-related schwannomatosis, which is associated with multiple surgical interventions, radiotherapy, and off-label use of bevacizumab. Unilateral vestibular schwannoma occurs sporadically in non-NF2-related schwannomatosis patients without drug treatment options. Tumour-infiltrating immune cells, especially macrophages and T-cells, play a role in the growth of vestibular schwannoma and show similarities between sporadic and NF2-related schwannomatosis tumours. However, there are differences in tumour presentation and patient characteristics between these two conditions. This study compared the tumour microenvironment of sporadic and NF2-related schwannomatosis vestibular schwannoma and found strong similarities in the immune profiles.
BRAIN COMMUNICATIONS
(2023)
Article
Oncology
Karin M. Kast, Esther L. John, John Hopper, Nadine Andrieu, Catherine Nogues, Emmanuelle Mouret-Fourme, Christine Lasset, Jean-Pierre Fricker, Pascaline Berthet, Veronique Mari, Lucie K. Salle, Marjanka Schmidt, Margreet G. E. M. Ausems, Encarnacion B. Gomez Garcia, Irma R. van de Beek, Marijke Wevers, D. Gareth Evans, Marc Tischkowitz, Fiona Lalloo, Jackie Cook, Louise Izatt, Vishakha Tripathi, Katie Snape, Hannah Musgrave, Saba Sharif, Jennie V. Murray, Sarah V. Colonna, Irene L. Andrulis, Mary B. Daly, Melissa C. Southey, Miguel de la Hoya, Ana Osorio, Lenka Foretova, Dita Berkova, Anne-Marie Gerdes, Edith Olah, Anna Jakubowska, Christian F. Singer, Yen Tan, Annelie Augustinsson, Johanna Rantala, Jacques Simard, Rita K. Schmutzler, Roger L. Milne, Kelly-Anne Phillips, Mary Beth Terry, David Goldgar, Flora E. van Leeuwen, Thea M. Mooij, Antonis C. Antoniou, Douglas F. Easton, Matti A. Rookus, Christoph Engel
Summary: The study found that height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.
BREAST CANCER RESEARCH
(2023)
Article
Health Care Sciences & Services
Stuart J. Wright, Martin Eden, Helen Ruane, Helen Byers, D. Gareth Evans, Michelle Harvie, Sacha J. Howell, Anthony Howell, David French, Katherine Payne
Summary: This study identified and quantified the resource use and associated costs of introducing a breast cancer risk-stratification approach into the English national breast screening program. Findings showed that using questionnaires and automated breast density measurement for risk prediction had low costs, but adding SNP testing significantly increased the costs.
MDM POLICY & PRACTICE
(2023)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
