Article
Chemistry, Multidisciplinary
Sif T. Linde, Vasco Corti, Vibeke H. Lauridsen, Johannes N. Lamhauge, Karl Anker Jorgensen, Nomaan M. Rezayee
Summary: This article presents a method for obtaining a versatile chiral biaryl structure through C-H halogenation reactions using high-valent Pd catalysis and chiral transient directing groups. The method is scalable, moisture and air insensitive, and in some cases, requires low Pd-loadings of only 1 mol%. Chiral mono-brominated, dibrominated, and bromochloro biaryls can be prepared in high yield and excellent stereoselectivity, serving as building blocks for various reactions with orthogonal synthetic handles.
Article
Chemistry, Multidisciplinary
Muhammad Asif Iqbal, Le Lu, Hina Mehmood, Ruimao Hua
Summary: This study reports a Cs2CO3-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO to afford biaryls in the absence of ligands. The cyano/nitro groups in biaryls are shown to be useful for further transformations. Additionally, the formation of dibenzofurans from reactions between arenes and 1-bromo-2-iodobenzene is reported. A radical mechanism for the formation of biaryls is proposed based on control experiments and theoretical studies.
Review
Chemistry, Physical
Yuji Nishii, Masahiro Miura
Summary: Dibenzo-fused five-membered heteroaromatic compounds, such as dibenzofuran, carbazole, and dibenzothiophene, are important structural units in various polycyclic heteroaromatic compounds. The intramolecular C-H/C-H biaryl coupling of diaryl (thio)ethers and amines based on palladium(II) catalysis under oxidative conditions is an effective method for their construction. This mini-review briefly summarizes representative examples of constructing structurally intriguing pi-extended polycyclic heteroaromatics through catalytic coupling reactions.
Article
Biochemistry & Molecular Biology
Meng-Yue Wang, Xue-Qing Zhu, Bao-Yin Zhao, Hong-Xia Zhang, Yong-Qiang Wang, Qiong Jia
Summary: In this study, the first palladium-catalyzed intramolecular C-H/C-H dehydrogenative coupling reaction of two simple arenes was reported to generate 5,6-dihydrophenanthridines. This approach has a wide substrate scope and good tolerance of functional groups, providing an efficient alternative synthesis route for important 5,6-dihydrophenanthridine compounds.
Article
Chemistry, Multidisciplinary
Zhao Li, Xu Wang, Yu-Ming Cui, Jun-Han Ma, Li-Lei Fang, Lu-Lu Han, Qin Yang, Zheng Xu, Li-Wen Xu
Summary: The study successfully combined palladium-catalyzed DKR with C-H functionalization to synthesize non-biaryl-atropisomer-type (NBA) axially chiral organosilanes, providing a new approach for the synthesis of multifunctional axially chiral organosilicon compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Juan-Carlos Lopez-Lopez, Delia Bautista, Pablo Gonzalez-Herrero
Summary: The first series of neutral, tris-chelate, phosphorescent Pt(IV) complexes, which combine specific ligands and react under mild conditions, were synthesized. The modulation of emission characteristics can be achieved by derivatization of the ligands.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Jitan Zhang, Jian Fan, Ziyi Guo, Yehe Wu, Jiaping Wu, Meihua Xie
Summary: A concise method for the synthesis of axially chiral biaryl aldehydes has been developed through Pd/amino acid-catalyzed interannular C-H arylation of biaryl aldehydes with aryl iodides. This reaction exhibits excellent enantioselectivity and good tolerance towards functional groups. The scalability and potential utility of this asymmetric catalytic protocol have been highlighted.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Raphael F. Fritsche, Tristan Schuh, Olga Kataeva, Hans-Joachim Knoelker
Summary: We report an iron-catalyzed asymmetric oxidative C-C coupling reaction which takes place at room temperature using air as the final oxidant. By using hexadecafluorophthalocyanine-iron(II) as the catalyst and the presence of catalytic amounts of an axially chiral biarylphosphoric acid, chiral 2,2'-diamino-1,1'-biaryls with up to 90% enantiomeric excess (ee) were obtained as confirmed by chiral HPLC analysis. A detailed mechanism involving a radical cation-chiral phosphate ion pair as the key intermediate leading to the observed asymmetric induction is proposed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Jitan Zhang, Jiaping Wu, Meihua Xie, Jian Fan, Yehe Wu, Ziyi Guo
Summary: In this study, a Pd(II)-catalyzed atroposelective C-H acyloxylation strategy was developed for the synthesis of biaryl aldehyde atropoisomers. Amino acids were used as the catalytic auxiliary and chiral pool. This strategy demonstrates a broad substrate scope, high yield (<= 90%), and excellent enantioselectivity (<= 99%), providing functionalized aldehydes through direct asymmetric C-H oxidation.
Article
Chemistry, Organic
Dianpeng Chen, Jianming Li, Xiuhua Zhang, Gongle Liu, Xin Wang, Yongwei Liu, Xuan Liu, Yingying Shan
Summary: A novel method for the synthesis of fused tetracyclic N-heterocycles is described using palladium-catalyzed cyclization of isocyanides with alkyne-tethered aryl iodides. The reaction involves a unique amino-to-alkyl 1,5-palladium migration/intramolecular C(sp(3))-C(sp(2)) coupling sequence. Isocyanide plays multiple roles in this transformation, serving as a C1 synthon, a C1N1 synthon, and the donor of C(sp(3)) for C(sp(3))-C(sp(2)) coupling, and it represents the only successful example of C(sp(3))-H activation of isocyanide.
Article
Chemistry, Multidisciplinary
Daigo Hayashi, Tomohiro Tsuda, Ryo Shintani
Summary: A palladium-catalyzed skeletal rearrangement has been developed to synthesize highly fused tetrahydrophenanthrosilole derivatives via bond exchange. The reaction conditions can be tuned to produce different products, fused dihydrodibenzosilepin derivatives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Iori Inoue, Koji Yamamoto, Shigeyoshi Sakaki, Tetsuro Murahashi
Summary: The formation of a heterometallic M-M' bond is crucial in constructing atomically precise bimetallic clusters and materials. By utilizing a sandwich framework of pi-conjugated unsaturated hydrocarbon ligands, a unique coordination environment is created that facilitates the unusual coupling of d(8) Rh-I and d(10) M-O (M=Pd, Pt), allowing the formation of a d sigma-type Rh-Pd bond.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lili Fang, Shuaixin Fan, Weiping Wu, Tielei Li, Jin Zhu
Summary: A low-cost, room temperature ruthenium catalytic method was developed for the synthesis of delta-diketones by coupling alpha-keto sulfoxonium ylides with cyclopropanols. The mild protocol showed a broad substrate scope (47 examples) and high product yield (up to 99%), with mechanistic studies supporting a cyclopropanol ring opening, sulfoxonium ylide-derived carbenoid formation, migratory insertion C-C bond formation pathway.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Tapas Kumar Das, Mrinalkanti Kundu, Biswajit Mondal, Prasanjit Ghosh, Sajal Das
Summary: A unique N,O-bidentate ligand catalyzed direct arylation of unactivated arenes to synthesize (Het)biaryl scaffolds efficiently under UV-irradiation at room temperature. The method showed good functional group tolerance and synthetic pathway, with potential applications in biological research.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Applied
Neil K. Adlington, Paul S. Siedlecki, Ian Derrick, Simon D. Yates, Andrew D. Campbell, Paula Tomlin, Thomas Langer
Summary: The plant-scale manufacture of AZD5069 faced challenges in removing palladium residues and dealing with the increasing costs of metal, ligand, and scavenger. An alternative copper-catalyzed reaction was developed and successfully operated.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Chemistry, Applied
Kushan C. Weerasiri, Danmin Chen, Derek I. Wozniak, Graham E. Dobereiner
ADVANCED SYNTHESIS & CATALYSIS
(2016)
Article
Chemistry, Multidisciplinary
Senzhi Zhao, Christiana N. Teijaro, Heng Chen, Gopal Sirasani, Shivaiah Vaddypally, Michael J. Zdilla, Graham E. Dobereiner, Rodrigo B. Andrade
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Physical
Joseph Becica, Graham E. Dobereiner
Article
Chemistry, Inorganic & Nuclear
Joseph Becica, Owen D. Glaze, Derek I. Wozniak, Graham E. Dobereiner
Article
Chemistry, Inorganic & Nuclear
Derek Wozniak, William A. Sabbers, Kushan C. Weerasiri, Luckym Dinh, Jacqueline L. Quenzer, Andrew J. Hicks, Graham E. Dobereiner
Article
Chemistry, Inorganic & Nuclear
Justin M. Kaplan, Damian P. Hruszkewycz, Iulia I. Strambeanu, Christopher J. Nunn, Kelsey F. VanGelder, Anna L. Dunn, Derek I. Wozniak, Graham E. Dobereiner, David C. Leitch
Article
Polymer Science
Evan M. Samples, Jeremy M. Schuck, Padmanabh B. Joshi, Katherine A. Willets, Graham E. Dobereiner
Article
Chemistry, Organic
Joseph Becica, Damian P. Hruszkewycz, Janelle E. Steves, Jennifer M. Elward, David C. Leitch, Graham E. Dobereiner
Editorial Material
Chemistry, Inorganic & Nuclear
Graham E. Dobereiner, Nilay Hazari, Nathan D. Schley
Article
Chemistry, Applied
Saibal Singh, Graham E. Dobereiner
Summary: This study investigates the factors that control the selectivity of internal alkyne hydration using gold(I) catalysts and finds that the choice of solvent influences the selectivity. At ambient temperature, using [(IPr)Au(NCMe)][IMP-H] (C1) as a precatalyst is effective for the hydration of alkyl/alkyl and alkyl/aryl acetylenes.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Joseph Becica, Owen D. Glaze, Damian P. Hruszkewycz, Graham E. Dobereiner, David C. Leitch
Summary: A specific combination of catalyst, solvent, base, and additives was crucial for both activity and selectivity in the Mizoroki-Heck arylation of electron-rich alkenes. This was especially important when translating screening hits into preparative-scale synthesis.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Inorganic & Nuclear
Derek Wozniak, Andrew J. Hicks, William A. Sabbers, Graham E. Dobereinere
DALTON TRANSACTIONS
(2019)
Review
Chemistry, Organic
Joseph Becica, Graham E. Dobereiner
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Senzhi Zhao, Christiana N. Teijaro, Heng Chen, Gopal Sirasani, Shivaiah Vaddypally, Owen O'Sullivan, Michael J. Zdilla, Graham E. Dobereiner, Rodrigo B. Andrade
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Physical
Huatao Yin, Lei Jin, Yuqin Qian, Xia Li, Yuhao Wu, Michael S. Bowen, Deirdre Kaant, Chao He, Derek I. Wozniak, Bolei Xu, Asa J. Lewis, Weiwei Shen, Ke Chen, Graham E. Dobereiner, Yan Zhao, Bradford B. Wayland, Yi Rao
ACS APPLIED ENERGY MATERIALS
(2018)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.