Article
Chemistry, Applied
Sedat Yurdakal, Marianna Bellardita, Ivana Pibiri, Leonardo Palmisano, Vittorio Loddo
Summary: The study investigated the partial photocatalytic oxidation of salicyl alcohol to salicylaldehyde in water under environmental friendly conditions using different TiO2 samples, and examined the effects of crystallinity degree, pH, and hole trap on the photocatalytic activity and product selectivity. The results showed that well-crystallized TiO2 samples at a pH of 11 yielded higher alcohol conversion and product selectivity values. The selectivity was also influenced by the position of the substituent group in the aromatic ring, with para position showing higher selectivity values.
Article
Chemistry, Organic
Pushpendra Mani Shukla, Aniruddh Pratap, Biswajit Maji
Summary: A diastereoselective N-heterocyclic carbene-catalysed reaction has been developed for accessing a new type of C-4-functionalized 2-amino-3-cyano-4H-chromene. Various enals and iminochromenes afforded the desired homoenolate addition product 2-amino-4H-chromenes in good yields and with moderate to good diastereoselectivities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Kota Sathish, Sakkani Nagaraju, Dhurke Kashinath
Summary: The application of dimethyl urea and L-tartaric acid as deep eutectic solvent (DES) for the synthesis of 2-(methylamino)-3-nitrospiro[chromene] and N-methyl-3-nitro-4H-chromen-2-amines in shorter reaction time with good yields is demonstrated. The method was extended to use water as reaction medium, still achieving good yields within 1 hour.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hossein Rouh, Yao Tang, Sai Zhang, Ahmed I. M. Ali, Kazimierz Surowiec, Daniel Unruh, Guigen Li
Summary: This work introduces a strategy for synthesizing functionalized 4H-chromene derivatives through a [4 + 2] cycloaddition reaction, resulting in several products under specific conditions. The products can be easily purified using Group-Assisted Purification (GAP) technology, avoiding traditional separation methods. The absolute configuration was determined by X-ray structure analysis.
Article
Chemistry, Multidisciplinary
Jayaprakash Rao Yerrabelly, Pavan Kumar Bathini, Hemasri Yerrabelly, Kishore Vadapalli
Summary: Ti/Zn-mediated McMurry coupling was used to synthesize a series of unusual CH2-CH2 tethered bis-chromones, showing chemoselectivity towards 4-oxo-4H-chromene-2-carbaldehydes. The study of reaction parameters and reagents further confirmed this selectivity, demonstrating a simple and efficient route for bis-chromone synthesis.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
S. Shanmuga Sundari, M. Mehala, N. Arunadevi, P. Kanchana, Salman S. Alharthi, E. Ranjith Kumar, Y. Al-Douri, A. F. Abd El-Rehim
Summary: The structural characteristics and optimized geometry of salicyl-N-methyl-4-stilbazolium tosylate (SMST), a derivative of the prominent electro-nonlinear optic crystal 4-(N,N-dimethylamino)-N-methyl-4-toluene sulfonate (DAST), have been investigated. The study reveals that SMST has the potential for nonlinear optical applications and meets the requirements of NLO materials.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
S. Asha, Anup Thomas, S. Suma, K. Retheesh, K. S. Sandhya, B. Siddlingeshwar, M. R. Sudarsanakumar
Summary: A novel Schiffbase, LMAP, was synthesized and characterized using X-ray diffraction and spectroscopic methods. The enol-imine (EI) reversible arrow keto-amine (KA) tautomeric behavior of LMAP was investigated using DFT methods in different solvents. The study found that the compound's structural preference depends on the solvent polarity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Jun Dong, Wei Chang, Youwei Chen, Xingcai Huang
Summary: A series of 2,4-dithiohydantoins were synthesized efficiently by regioselective reactions of phenacyl sulfoxides bearing 1-methyl-1H-tetrazole and N-substituted thioureas. The proposed mechanism involves the generation of alpha-sulfines, carbonphilic attack of sulfines by substituted thioureas, and dehydration condensation. This method provides a safe strategy for the preparation of 2,4-dithiohydantoins.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Jun Dong, Wei Chang, Youwei Chen, Xingcai Huang
Summary: A series of 2,4-dithiohydantoins were successfully synthesized in moderate to excellent yields from phenacyl sulfoxides bearing 1-methyl-1H-tetrazole and N-substituted thioureas. The proposed mechanism involves the generation of α-sulfines from sulfoxides through thermolytic elimination, carbonphilic attack of sulfines by substituted thioureas, and dehydration condensation. This method provides a safe strategy for the preparation of 2,4-dithiohydantoins.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Siva Hariprasad Kurma, Sai Teja Kolla, Balasubramanian Sridhar, China Raju Bhimapaka
Summary: 3-(2,2-dichloroacetyl)-2H-chromen-2-ones were synthesized for the first time by treating salicyl N-tosylhydrazones with ethyl 4,4,4-trichloro-3-oxobutanoate in the presence of La(OTf)(3) and RuCl3 center dot 3H(2)O. The formation of chromenones involved C-C, C-O bond formations, detosylation, and dechlorination protocols, with the structure of one compound confirmed by single-crystal X-ray analysis. Additionally, treatment of salicyl N-tosylhydrazones with dimethyl (1-diazo-2-oxopropyl)-phosphonate in the presence of K2CO3 and RuCl3 center dot 3H(2)O provided (E)-N '-(2-hydroxybenzylidene)-N,4-dimethylbenzenesulfono hydrazide.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Li Dong, Xiaoqing Wang, Yudi Nie, Shuo Yu, Haotong Li, Qian Zhao, Zixuan Fan, Yuqian Wang, Xiaoting Tan, Zhengsen Yu
Summary: A simple and metal-free method for perfluoroalkylation of 4-quinolones has been developed using sodium perfluoroalkyl sulfinates and ammonium peroxodisulfate in DMSO under mild conditions. The results show high yields and broad functionality. Experimental results suggest a radical mechanism pathway involved in this method.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Swati D. Jadhav, Suresh S. Patil
Summary: This article describes a highly efficient and convenient green method for the synthesis of 2-amino 4H-chromene derivatives in an ethanol-water system using a highly efficient natural catalyst, calcined eggshell (CES). The inexpensive and green catalyst CES is derived from waste natural resources. This method offers mild reaction conditions, short reaction times, and clean work up procedures, providing an economical and environmentally friendly alternative to existing methodologies.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Organic
Gurdeep Singh, Sonam Sharma, Rekha, Rajat Pandey, Rupali Singh, Tarunjeet Kumar, Ramasamy Vijaya Anand
Summary: A one-pot method has been developed for synthesizing oxygen-containing heterocycles in moderate to excellent yields through a series of chemical reactions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Bo Zhu, Tianxiao Yang, Yingxin Gu, Shuping Zhu, Gongming Zhu, Junbiao Chang
Summary: In this study, a highly enantioselective amination at the C-2 position of 2-perfluoroalkyl-oxazol-5(2H)-ones to phenylazocarboxylates is achieved using a (1R,2R)-cyclohexane-1,2-diamine-derived urea-tertiary amine as a bifunctional catalyst. Two efficient asymmetric transformation processes leading to chiral N,O-aminal derivatives with a quaternary center in good yields and excellent enantioselectivities are described. These strategies enable the construction of N,O-acetal derivatives containing perfluoroalkyl and amino moieties with high enantioselectivity.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Roghayeh Ferdousian, Farahnaz K. Behbahani, Bita Mohtat
Summary: This research paper presents the synthesis and characterization of a magnetic nanoparticle catalyst, Fe3O4@Sal@Cu, which is green and retrievable. The catalyst was analyzed using FTIR, XRD, EDX, and TGA, and its catalytic activity in the synthesis of 2-amino 4H-chromenes was investigated. The catalyst showed good-to-excellent yields under mild reaction conditions and had the advantages of being eco-friendly, easy to handle, highly reusable, and magnetically separable.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
