Journal
TETRAHEDRON
Volume 65, Issue 29-30, Pages 5669-5675Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.05.039
Keywords
beta-Peptides; Crystal structure; Hydrogen bonds; Cyclobutanes
Categories
Funding
- Ministerio de Educacion y Ciencia (MEC) [CFQ2006-01080, CrQ2007-61704/BQU]
- Generalitat de Catalunya [GQ (2005SGR-103]
Ask authors/readers for more resources
The synthesis of some representative compounds of a new class of cyclobutane-containing beta-peptides starting from (-)-verbenone as a chiral precursor is presented. In these products, the cyclobutane moiety is not a part of the peptide backbone but a bulky substituent at the beta(3)-position. These compounds have been carefully characterized and studied on the basis of the combined use of several experimental techniques together with molecular modeling by means of theoretical calculations. In the solid state, the non-cyclic beta-peptides adopt a hairpin-like molecular folding ruled by intermolecular hydrogen bonds in the crystal packing. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available