Journal
TETRAHEDRON
Volume 65, Issue 18, Pages 3682-3687Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.02.059
Keywords
Fluoroadamantane; Functionalization; Substitution; Fluoromemantine
Categories
Ask authors/readers for more resources
Selective introduction of functional groups on the tert-carbon of adamantane was performed by substitution with fluorides. A methyl, phenacyl, aryl, cyclohexyl, alkoxy, or azido group was introduced into the adamantane skeleton without influencing the other functional groups present. Various functionalized adamantanes were synthesized using this scheme. A fluorinated analog of memantine (3-fluoro-5,7-dimethyl-1-adamantylammoniurn acetate 25) was synthesized from methyl 3,5-dimethyladamantane-1-carboxylate 6. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available