Article
Chemistry, Physical
Igor Beckers, Besir Krasniqi, Prashant Kumar, Daniel Escudero, Dirk De Vos
Summary: Two indoles linked by a C-C bond have emerged as promising scaffolds in medicinal chemistry. In this study, selective C-H/C-H cross-coupling of N-substituted indoles without directing groups was achieved under mild conditions, driven by molecular oxygen. The ligand-controlled selectivity can be exploited to achieve selective cross-coupling between two indoles with different substitution patterns.
Article
Chemistry, Multidisciplinary
Dominik Lichte, Nico Pirkl, Gregor Heinrich, Sayan Dutta, Jonas F. Goebel, Debasis Koley, Lukas J. Goossen
Summary: This study demonstrates the achievement of para-C-H arylation of non-activated aryl halides with anilines using a base-assisted metalla-tautomerism approach. The challenge of directing functionalization towards the furthest C-H group has been overcome.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Md. Emdadul Hoque, Jin-Quan Yu
Summary: In this study, we report a new method for the gamma-arylation and gamma-lactonization of aliphatic acids, enabled by a L,X-type CarboxPyridone ligand catalyzed Pd(II) reaction. A wide range of gamma-arylated gamma-lactones can be efficiently synthesized in a single step, and the arylated lactones can be further converted into disubstituted tetrahydrofurans, which are prominent scaffolds in bioactive molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Xiao-Wen Wang, Rui-Xue Li, Yang Deng, Ming-Qiu-Hao Fu, Ya-Nan Zhao, Zhi Guan, Yan-Hong He
Summary: This article proposes a new method for the direct hydroxylarylation of unactivated benzylic carbons (sp3/sp2/sp) without the need for pre-functionalized benzylic alcohols, aromatic aldehydes, or ketones. It features direct functionalization of unactivated benzylic C(sp3)-H bonds and benzylic sp2/sp-carbons, mild conditions (open air, room temperature), an environmentally friendly procedure (without any external catalyst/mediator/additive), and direct access to sterically hindered alcohols from inexpensive and readily available alkyl/alkenyl/alkynylbenzenes. Mechanistic studies strongly support the proposed radical-radical cross-coupling between transient ketyl radicals and persistent radical anions. Gram-scale synthesis and diversification of drug derivatives demonstrate the practical potential of this protocol.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tatsuhiro Uchikura, Sotaro Kato, Yudai Makino, Megumi J. J. Fujikawa, Masahiro Yamanaka, Takahiko Akiyama
Summary: Desymmetrization is a crucial technique for synthesizing chiral compounds, especially chiral biaryls. This study presents an enantioselective synthesis of axially chiral biaryls through desymmetrization using chiral palladium phosphate as the catalyst for C(sp(3))-H activation. Mechanistic investigations reveal that C-H activation plays a crucial role in determining the rate and enantiomeric selectivity. To the best of our knowledge, this is the first report on the asymmetric desymmetrization of axially chiral compounds via C(sp(3))-H activation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Anton Kudashev, Olivier Baudoin
Summary: A ligand-controlled site-selective C(sp(3))-H arylation of heteroaromatic ketones has been developed using Pd catalysis, with selective reactions occurring at the alpha- or beta-position of the ketone side-chain. Addition of a pyridone ligand enables switching from alpha- to beta-arylation. The alpha-arylation process demonstrates broad scope and high site- and chemoselectivity, while the beta-arylation is more limited, with mechanistic investigations suggesting different pathways for the two processes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jyoti Dhankhar, Micha D. Hofer, Anthony Linden, Ilija Coric
Summary: This article presents a new selectivity mode for C-H arylation reactions, which is the preference for C(sp(2))-H activation next to alkyl groups. The study results indicate that this preference is related to the non-covalent interactions between the catalyst and the substrate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Stavros K. Kariofillis, Abigail G. Doyle
Summary: In recent years, the development of light-driven reactions has made significant advancements in synthetic organic chemistry, particularly in combining photoredox and nickel catalysis for challenging cross-coupling reactions. The question of whether photo-induced activation of the nickel catalyst itself could lead to new approaches to cross-coupling has been explored. By utilizing a visible-light-driven mechanism for chlorine radical formation and conducting mechanistic investigations on organometallic Ni complexes relevant to cross-coupling, the study aims to facilitate new catalyst design and develop novel synthetic methods.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Physical
Hang Wang, Huiling Li, Xiahe Chen, Chunlin Zhou, Shangda Li, Yun-Fang Yang, Gang Li
Summary: In this study, a chiral ligand-controlled, asymmetric remote meta-C-H activation method was reported. By using a specific chiral ligand and Pd(II) catalyst, asymmetric C-H olefination and arylation of arenes were achieved. The origins of enantioselectivity were explained through density functional theory calculations.
Article
Chemistry, Physical
Adrian Tlahuext-Aca, Sarah Yunmi Lee, Shu Sakamoto, John F. Hartwig
Summary: A new method for the direct catalytic arylation of simple arenes using aryl bromides is described. The method does not rely on directing groups and instead utilizes a synergistic catalytic cycle involving phosphine-ligated silver complexes and palladium catalysts. Mechanistic experiments indicate that cleavage of the C-H bond by silver is the rate-determining step in the catalytic cycle.
Article
Chemistry, Organic
Jian Zhang, Xinzhe Shi, Henri Doucet
Summary: This study explores a Pd-catalyzed annulative pi-extension reaction of 1-arylpyrroles using 1,2-dihalobenzenes as coupling partners, leading to the selective synthesis of pyrrolo[1,2-f]phenanthridines. The higher reactivity of the pyrrole C2-H bond allows for successful access to substituted pyrrolo[1,2-f]phenanthridines.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Marc Renom Carrasco, Walid Khodja, Clement Demarcy, Laurent Veyre, Clement Camp, Chloe Thieuleux
Summary: The study presents the development of Pd-supported catalysts for the selective C-3 arylation of free indole, showing that catalysts with isolated surface thiol groups and high Pd loading exhibit the highest activity. By optimizing the design, high catalytic performance with low metal leaching during the reaction can be achieved.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Verena Sukowski, Manuela van Borselen, Simon Mathew, M. Angeles Fernandez-Ibanez
Summary: By reversing conventional site-selectivity of C-H activation, a new catalytic system based on palladium/norbornene and an S,O-ligand for meta-C-H arylation of aryl ethers is reported, which outperforms previously reported systems. This system shows unique ability to use alkoxyarene substrates with different substituents, as well as tolerate ortho-substituted aryl ethers by employing novel norbornene mediators. Moreover, monoarylation of alkoxyarenes is achieved for the first time, enabling rapid introduction of a second, different aryl coupling partner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Hai-Yun Huang, Amal Benzai, Xinzhe Shi, Henri Doucet
Summary: Researchers are focused on developing different procedures for direct functionalization of two different C-H bonds of the same organic molecule, which is currently an important research topic in organic chemistry. Over the past decade, the number of tools to control regiodivergent C-H bond functionalizations has significantly increased.
Article
Chemistry, Multidisciplinary
Daniel Sowa Prendes, Florian Papp, Nagesh Sankaran, Nardana Sivendran, Frederike Beyer, Christian Merten, Lukas J. Goossen
Summary: Arylglycines, which are important pharmacophores in several top-selling drugs, can now be synthesized from abundant aryl chlorides using a Pd-catalyzed Schollkopf-type amino acid synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Civil
Jiaoe Wang, Yanan Li, Jingjuan Jiao, Haitao Jin, Fangye Du
Summary: This study explores the spatiotemporal dynamics and determinants of bus ridership at the community level using the spatial Durbin model (SDM). The results reveal distinct temporal dynamics on weekdays and weekends, as well as different spatial patterns across various time slots. The study also identifies key determinants that vary depending on the day of the week and time slot.
Article
Management
Yanan Li, Jun Lin, Yanjun Qian, Dehong Li
Summary: This study uses a game-theoretic approach to analyze the optimal government Feed-in Tariff (FiT) for biomass power plants and the impact of biomass feedstock competition and independent suppliers. The findings suggest that government should subsidize biomass power plants with high competitiveness, and the involvement of independent suppliers reduces the efficiency of the subsidy.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Jingtao Lei, Yanan Li, Haifei Xu
Summary: This article studies the biomechanical properties of musculoskeletal tissue during pelvic fracture reduction and provides reference for robot-assisted pelvic fracture reduction by establishing a finite element model to simulate muscle deformation.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Review
Engineering, Mechanical
Yuanchao Zhang, Jianwei Cheng, Wei Xu, Chiming Wang, Jiaqi Liu, Yanan Li, Shuqi Yang
Summary: This article analyzes the vibration and noise control issues of underwater ships and proposes 7 damping technologies for engineering applications. Particle damping technology has high application value in the harsh environment of underwater vessels and can be combined with dynamic vibration absorbers. The multi-particle damping vibration absorber is an effective solution to the problem.
JOURNAL OF VIBRATION ENGINEERING & TECHNOLOGIES
(2023)
Article
Materials Science, Ceramics
Hu Wang, Yanan Li, Xiaoyi Liu, Yunkai Dong, Guixia Liu, Jinxian Wang, Dan Li, Wensheng Yu, Xiangting Dong
Summary: In this study, a novel red phosphor Na3Li3In2F12:Mn4+ with good waterproof stability was successfully synthesized. The phosphor showed narrow emission bands in the range of 590-680 nm under blue light excitation. Compared to commercial red phosphor K2SiF6:Mn4+, Na3Li3In2F12:Mn4+ exhibited better waterproof stability, with the phosphorescence intensity remaining at 80% after being soaked in water for 360 min. Finally, warm white light-emitting diodes (WLEDs) with a color rendering index (CRI) of 87 and correlated color temperature (CCT) of 3386 K were fabricated using blue InGaN chip, YAG:Ce3+ yellow phosphor, and Na3Li3In2F12:Mn4+ red phosphor.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Mengdie Xu, Jia Wei, Xueru Cui, Jiamei Li, Guoping Pan, Yanan Li, Zijian Jiang, Xiruo Niu, Nan Cui, Jun Li
Summary: This study prepared a ternary metal-layered double hydroxide (CoFeCe-LDH) nanoparticle on carbon felt via one-pot hydrothermal strategy for heterogeneous electro-Fenton (HEF) cathode. The optimal CoFeCe-LDH@CF cathode demonstrated high oxygen reduction activity, low resistance, and efficient degradation of DOX over a wide pH range (pH = 1-9).
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Dongmei Liu, Xuejia Chen, Hui Zeng, Chang Liu, Biyu Tang, Yan Li, Lishan Zhang, Min Zhang
Summary: A novel, low-cost soap-film sensor was developed for detecting ammonia in environmental water and saliva. The sensor consisted of a 3D printed circular frame with stainless steel electrodes and a manually generated soap film. The conductivity of the soap film was measured to quantify the ammonium concentration in liquid samples. The method showed good analytical performance and had advantages over a reference indophenol blue method.
MICROCHEMICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Feng Cao, Rui Ding, Zhiyan Rui, Xuebin Wang, Zhen Meng, Bin Zhang, Weiwen Dong, Jia Li, Jianguo Liu, Xiangfen Jiang
Summary: This review summarizes the methods of designing nanocatalysts and optimizing the catalyst layer structure to achieve low-Pt loading MEAs. Different strategies and their corresponding effectiveness are summarized and compared. Finally, future directions for affordable, highly active, and durable PEMFCs are discussed and proposed.
Article
Chemistry, Applied
Xiaomeng Yang, Yan Yu, Panfeng Wu, Juan Liu, Yanan Li, Linlan Tao, Rong Tan, Xiaojiang Hao, Chunmao Yuan, Ping Yi
Summary: In this study, three new compounds were isolated from Aglaia odorata and their structures were elucidated. Further investigation revealed that these compounds exhibited excellent inhibitory activities on alpha-glucosidase, better than the positive control. Additionally, some of the compounds also showed moderate inhibitory activities against butyrylcholinesterase and PTP1B.
NATURAL PRODUCT RESEARCH
(2023)
Article
Engineering, Marine
Pengwei Hu, Ying Cui, Chenyu Zhao, Yanan Li, Boyang Li
Summary: This study analyzes the influence of the front outrigger inclination angle on the resistance of the pentamaran using CFD method and predicts the resistance of the pentamaran in static water and waves using the unsteady RANS equation. The influence of the front outrigger inclination angle on the resistance performance of the pentamaran under different working conditions is calculated and discussed. Further analysis is conducted on the influence of the change of the front outrigger inclination angle on the resistance, and the effects of free surface wave-making and hull pressure are discussed. The results indicate that adjusting the front outrigger inclination angle can reduce the resistance of the pentamaran.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Microbiology
Yanan Li, Man Qi, Qi Zhang, Zhixu Xu, Yan Zhang, Yuqian Gao, Yuancheng Qi, Liyou Qiu, Mingdao Wang
Summary: This study cloned, expressed and characterized five ACOs from the straw mushroom and the oyster mushroom, finding that they shared conserved residues with plant ACOs and had 1-2 of the conserved ACO motifs. It was also discovered that the horizontal transfer of fungal ACOs possibly facilitated fungal-plant symbioses, plant-land colonization and further evolution to form seeds.
Article
Engineering, Chemical
Yanan Li, Yan Wang, Wei Wang, Xiao Yu, Li Zhang, Liu Deng, You-Nian Liu
Summary: Development of heterojunction is an effective strategy to enhance the hydrogen production performance of photocatalysts. In this study, a 2D/2D Z-scheme heterojunction-coupled Zn0.4Cd0.6S with g-C3N4 was fabricated using in situ hydrothermal approach. The sheet-on-sheet architecture allowed full contact of heterojunction, facilitating interfacial charge transfer and increasing surface-active sites. Moreover, the Zn-N coordination bond provided a strong interfacial interaction and spatially separated photogenerated charges along the Z-scheme mechanism. The optimal photocatalyst exhibited high hydrogen production rates (7.69 mmol g-1 h-1) under visible-light irradiation without any cocatalysts, four times higher than the g-C3N4 photocatalyst with Pt as a cocatalyst. The catalyst also showed long-term stability of up to 50 hours. Thus, a direct Z-scheme heterojunction with intimate contact and a well-definite bridging chemical bond holds promise for hydrogen generation.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Xi-Li Li, Ailing Wang, Yanan Li, Congli Gao, Minghui Cui, Hong-Ping Xiao, Liming Zhou
Summary: Using enantiomerically pure bidentate and tridentate N-donor ligands, two eight-and nine-coordinated YbIII enantiomeric pairs were obtained. Interestingly, these pairs show distinct degrees of chirality and significant differences in NIR photoluminescence, CPL, and SHG.
INORGANIC CHEMISTRY
(2023)
Article
Computer Science, Information Systems
ZhenFeng Zhang, ChuHua Huang, RenJing Huang, YaNan Li, YiFan Chen
Summary: This paper proposes a new unsupervised learning method for estimating illumination by observing indoor video sequences under changing illumination and learning the intrinsic decomposition of the sequences. A new network framework is introduced, along with two new dense spatio-temporal smoothness loss functions. The method shows good performance on several specific metrics and has strong generalization.
MULTIMEDIA SYSTEMS
(2023)
Article
Chemistry, Analytical
Yanan Li, Xin Hua, Jiajia Wang, Baokang Jin
Summary: A novel electrochemical sensing platform was developed for sensitive detection of interleukin 6 (IL-6). The label-free aptasensor was fabricated by modifying the glassy carbon electrode (GCE) with a nanocomposite of carboxylated multi-walled carbon nanotubes (cMWCNTs), cobalt hex-acyanoferrate (CoHCF), and gold nanoparticles (AuNPs). The nanocomposite enhanced electron transfer rate, increased intercalation of signaling molecules, and allowed immobilization of biomolecules. The aptasensor demonstrated good electrochemical characteristics and biocompatibility, with a linear range from 0.5 pg/mL to 1000 pg/mL and a low detection limit of 0.17 pg/mL. It also exhibited selectivity, stability, and reproducibility, making it suitable for clinical research and diagnostic applications.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
