Article
Chemistry, Organic
Chao Han, Lei Nie, Xiao Han, Yan Zhang, Kelei Sun, Lei Shi, Guanghua Cui, Wei Meng
Summary: A one-pot three-component reaction was developed to synthesize 1,5-benzodiazepine derivatives with pyrrolidinone, showing significant anti-BVDV activity with good safety profiles. This method provides a promising strategy for the research of anti-BVDV agents.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Jing Li, Zhenfang Hao, Kaiyue Zhang, Lanzhi Wang
Summary: A total of 43 novel 1,5-benzodiazepine compounds were efficiently synthesized via one-pot multicomponent and tandem reactions, providing a green, environmentally friendly, and simple synthetic approach for the construction of these compounds.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Zi-Qi Geng, Chunhui Zhao, Hao-Dong Qian, Si-Jia Li, Hao Peng, Hao Xu
Summary: A Cu/Ag relay catalyzed cascade reaction was used to synthesize chiral triazole-fused pyrazine scaffolds. This method utilized a novel N,N,P-ligand and showed high efficiency, functional group tolerance, excellent enantioselectivities, and a broad substrate scope using readily available starting materials.
Article
Chemistry, Physical
Mohammad Mehdi Vahedi, Sakineh Asghari, Mahmood Tajbakhsh, Mojtaba Mohseni, Asieh Khalilpour
Summary: Pyrano[3,2- e]pyrazaolo[1,5-a]pyrimidine derivatives were efficiently synthesized through three-component reactions, with high yields of 80-89%. The synthesized compounds were structurally identified using various analytical techniques. The compounds were evaluated for their anti-cancer, antioxidant, and antibacterial activities, and compound 4l showed the most potent anti-cancer activity and compound 4h exhibited the highest free radical scavenging effect. The synthesized compounds also exhibited modest antibacterial activity against Gram-positive bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Zhao Long, Yang Maolin, Chen Haoran, Ding Mingwu
Summary: A new one-pot synthesis of 3,4-dihydroquinazolines by diethyl azodicarboxylate (DEAD)-promoted oxidative Ugi/aza-Wittig reaction was developed. The reactions of iminophosphoranes 5, N-aryl-1,2,3,4-tetrahydroisoquinolines 6 and acids 7 produced 3-(tetrahydroisoquinolin-1-formyl) substituted 3,4-dihydroquinazolines 8 in moderate to good yields in the presence of DEAD by tandem oxidative Ugi/aza-Wittig reaction.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Sure Siva Prasad, Dirgha Raj Joshi, Ikyon Kim
Summary: A method to directly access diarylmethylazides, versatile intermediates, was developed from commercially available starting materials via a three-component coupling reaction in the presence of a catalyst. This approach simplifies the synthetic steps and provides a versatile intermediate for further transformations.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Medicinal
Tommaso Felicetti, Maria Sole Burali, Chin Piaw Gwee, Kitti Wing Ki Chan, Sylvie Alonso, Serena Massari, Stefano Sabatini, Oriana Tabarrini, Maria Letizia Barreca, Violetta Cecchetti, Subhash G. Vasudevan, Giuseppe Manfroni
Summary: A sustainable three-component reaction (3CR) was developed for synthesizing PBTZ analogues with broad-spectrum anti-flavivirus activity, with compound 22 identified as the best inhibitor in a new series. These results support PBTZ derivatives as promising anti-flavivirus agents for further development studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Simra Faraz, Abu Taleb Khan
Summary: A green synthesis of 2,3-diarylquinolines is presented using a one-pot three-component reaction with arylamines, benzaldehyde, and styrene oxide. The reaction is catalyzed by 20 mol% p-TSA center dot H2O at 120 degrees C and does not require metal catalysts, additives, or extra oxidants. This method is advantageous due to its simplicity, wide substrate scope, short reaction time, high atom economy, regioselectivity, and good yields. In a single step, it forms one C-N bond and two C-C bonds.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Wang Mingliang, Yin Liuyan, Wen Tiantian, Zhang Xiao, Gao Jie, Wang Lanzhi
Summary: 1,5-Benzodiazepine compounds are nitrogen heterocyclic compounds with significant biological and pharmacological activities. A one-pot green synthesis method allows for the efficient synthesis of multifunctional 1,5-benzodiazepine compounds under mild conditions. This method provides a new approach for the green synthesis of benzodiazepines.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Fei Ma, Jie Li, Shuning Zhang, Yuang Gu, Tingting Tan, Wanting Chen, Shuyue Wang, Hongtao Xu, Guang Yang, Richard A. Lerner
Summary: Metal-catalyzed one-pot reaction using DNA encoding has been developed for the formation of C(sp(2))-C(sp(3)) and C(sp(3))-S bonds. The reaction shows wide substrate scopes and moderate to excellent yields, greatly expanding the chemical space of DNA-compatible reactions and the molecular scaffold diversity of DNA-encoded libraries.
Article
Chemistry, Applied
Vighneshwar Shridhar Bhat, Anna Lee
Summary: A one-pot, three-component synthesis of 3-arylsulfonylated thioflavones has been developed, where the reactions were carried out without using any catalysts or additives, and the desired products were obtained through intramolecular radical cyclization. This method provides an alternative route for the synthesis of thioflavone derivatives, which have been found in various bioactive compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
T. T. Wen, L. Z. Wang
Summary: A magnetic core-shell copper-based nanocatalyst was successfully prepared and characterized using various analytical techniques. The highly efficient catalyst exhibited excellent catalytic activity and selectivity in the one-pot synthesis of diester/methyl-substituted polycyclic fused 1,5-benzodiazepines. The catalyst's easy recovery and reusability, along with its practicality, environmental friendliness, and economic attractiveness, make it a promising candidate for various applications.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Masoud Mohammadi Vala, Mohammad Bayat, Yadollah Bayat
Summary: This method offers a simple and efficient approach for the synthesis of dihydro-8H-acenaphtho[1',2':4,5]pyrrolo[1,2-a]imidazole-diol derivatives through a one-pot, four-component reaction. The reactions are conducted in ethanol at reflux without the need for a catalyst, resulting in good to high yields with experimental simplicity and easy purification.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Applied
Alexis Truchon, Aurelien Dupeux, Sandra Olivero, Veronique Michelet
Summary: A gold-catalyzed orthogonal tandem reaction using HFIP as a Lewis acid has been developed to access carbocyclic ketone on naphthalene substrates. The yield of cyclic ketones ranged from 15% to 91% using a variety of acenaphthylene carbaldehydes. The mechanism involved a cyclization process followed by an [Au]-HFIP interaction for the final rearrangement. The gram-scale transformation and post-functionalization bromination were successfully carried out.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Sachin Bangale, Valmik Jondhale, Dattatraya Pansare, Pravin Chavan
Summary: A versatile and efficient three-component one-pot (2π + 2π) cycloaddition reaction was used for the synthesis of substituted azetidines in good yields. The ZnCr2O4 nanoparticles catalyst could be easily recovered and reused, and the synthesized products were characterized by various analytical methods.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.