Journal
TETRAHEDRON
Volume 64, Issue 6, Pages 1114-1134Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.10.058
Keywords
multicomponent Ugi reaction; cyclic imine; pyrrolidine; peptidomimetics; acylation
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An efficient and convergent Ugi synthesis of enantiomerically pure N-acyl-2,5-disubstituted pyrrolidines was coupled with an appropriate secondary transformation to give two series of bicyclic derivatives, namely hexahydro pyrrolo-oxazocinediones and -diazepinediones. (c) 2007 Elsevier Ltd. All rights reserved.
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