Article
Chemistry, Multidisciplinary
Ryoto Oya, Kenji Ota, Masaaki Fuki, Yasuhiro Kobori, Masahiro Higashi, Kazunori Nagao, Hirohisa Ohmiya
Summary: The biomimetic design of a transition metal complex based on the iron(iv)-oxo porphyrin & pi;-cation radical species has been translated to an & alpha;-ketoacyl phosphonium species for ortho-selective oxygenation of anilines. Visible light irradiation activates the excited state of the auxiliary, which acts as a transient oxidant, providing high regioselectivity and chemoselectivity.
Article
Chemistry, Organic
Jiahua Chen, Jun Wei Lim, Shunsuke Chiba
Summary: An facile method for the conversion of 2-piperidones and 2-pyrrolidones into 2-cyano-3-iodo piperidines or pyrrolidines has been achieved through a sequence of controlled hydride reduction, silylation, iodination, and cyanation, resulting in high diastereoselectivity and good yields.
Article
Engineering, Chemical
Yujie Hu, Guohua Ye, Qi Zuo, Wei Xiao, Xuanxiong Kang, Xueyin Liang, Siqin Zhu
Summary: A new method of ilmenite surface modification based on sodium chlorite activation using sodium oleate as a collector was developed. Sodium chlorite induced a chemical reaction on the surface of ilmenite, converting more Fe2+ to Fe3+ and strengthening the adsorption of sodium oleate. The activation of ilmenite by sodium chlorite significantly increased the number of active sites on the surface and improved the floatability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Organic
Lalita Tanwar, Jonas Boergel, Johannes Lehmann, Tobias Ritter
Summary: Iodoarenes are versatile intermediates and common synthetic targets in organic synthesis. The strategy presented here allows for selective C-H iodination of (hetero)arenes with a broad functional group tolerance, showcasing the utility and differentiation from other iodination methods for a set of carboarenes and heteroarenes.
Article
Agricultural Engineering
Qianlong Li, Yuriy Malyar, Aleksandr Kazachenko, Zhouyang Xiang
Summary: Xylans with naturally occurring acetylation play a vital role in the functionalities of plant cell walls and exhibit excellent dispersing properties applicable to fine chemicals and advanced materials. This study investigates the effects of different treatments on the dimethyl sulfoxide (DMSO) extraction of xylan from birch wood, including holocellulose production using sodium chlorite as the delignification method, solvent exchange, drying, and ball-milling. The findings provide valuable insights into the extraction and characterization of xylans, paving the way for further research and applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Ryoto Oya, Kenji Ota, Masaaki Fuki, Yasuhiro Kobori, Masahiro Higashi, Kazunori Nagao, Hirohisa Ohmiya
Summary: The biomimetic design based on the iron(iv)-oxo porphyrin & pi;-cation radical species in cytochrome P450 enzymes has been extensively studied. In this study, the functions of this species were translated to an & alpha;-ketoacyl phosphonium species comprised of non-metal atoms and used as a light-activated oxygenation auxiliary for ortho-selective oxygenation of anilines. The process exhibited high regioselectivity and chemoselectivity.
Article
Chemistry, Multidisciplinary
Yaxin Wang, Zehui Cao, Qin He, Xin Huang, Jiaxi Liu, Helfried Neumann, Gong Chen, Matthias Beller
Summary: A simple and efficient method has been developed for activating perfluoroalkyl iodides using tBuONa or KOH, without the need for expensive photo- or transition metal catalysts. This method enables various transformations including alpha-sp(3) C-H amidation reactions of alkyl ethers and benzylic hydrocarbons, C-H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich pi bonds. Mechanistic studies have shown that these reactions are mediated by halogen bond interactions between perfluoroalkyl iodides and tBuONa or KOH, leading to the homolysis of perfluoroalkyl iodides under mild conditions.
Article
Engineering, Multidisciplinary
Ahmed S. Elmannaey, Hala E. E. Fouad, Youssef G. Youssef
Summary: This paper aims to investigate the feasibility of stabilizing swelling soil using only sodium silicate, and the results show that using 10% sodium silicate alone can successfully improve the soil's mechanical characteristics and eliminate its swelling potential.
AIN SHAMS ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Franziska K. Merkt, Flaminia Mazzone, Shabnam Shaneh Sazzadeh, Lorand Bonda, Larissa K. E. Hinz, Irina Gruber, Karin Buchholz, Christoph Janiak, Klaus Pfeffer, Thomas J. J. Mueller
Summary: A gold-catalyzed cycloisomerization reaction was used to synthesize a series of luminescent silylated heterocycles, whose optical properties can be tuned by different functional groups. These compounds also showed promising anti-parasitic activities, making them potential candidates for novel anti-parasitic therapies.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Engineering, Environmental
Yu Liu, Linlin Qin, Yiming Qin, Tong Yang, Haoran Lu, Yulong Liu, Qiqi Zhang, Wenyan Liang
Summary: Co/NC/PAC electrode was prepared by compounding ZIF-67 with powder-activated carbon for the electrocatalytic treatment of nitrogen-containing heterocyclic compounds. The degradation efficiency of the four compounds reached 90.2-93.7% under optimal conditions, and the degradation order was pyridazine < pyrimidine < pyrazine < pyridine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Green & Sustainable Science & Technology
Peiyao Wen, Yong Xu, Junhua Zhang
Summary: Alkali incubation improved the xylan hydrolysis efficiency of SC-pretreated poplar, leading to higher yields of glucose and xylose. The reduction of lignin and chlorine contents, as well as the decrease in cellulase loading, contributed to the increased sugar yields.
Article
Chemistry, Organic
Na Meng, Wensheng Yu, Takao Suzuki, Maofen Chen, Zhiqi Qi, Bin Hu, Jianming Bao, John S. Debenham, Robert Mazzola, Joseph L. Duffy
Summary: The deoxygenation of substituted methanol derivatives using PPh3/I-2/imidazole was successful for secondary or tertiary alcohols with one or two heteroaryl groups, and it tolerated acid-sensitive heterocycles. While it worked for methanol derivatives with 2-pyridyl, 4-pyridyl, or other heterocyclic groups, those with 3-pyridyl or heterocyclic groups that do not allow resonance of the negative charge to a nitrogen atom did not undergo deoxygenation under this condition.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Engineering, Chemical
Yafeng Fu, Ying Hou, Run Wang, Yulian Wang, Xiaofeng Yang, Zhenhai Dong, Jianjun Liu, Xiaofei Man, Wanzhong Yin, Bin Yang, Hao Tang
Summary: Chlorite impairs the hematite reverse flotation pulp, but the addition of sodium alginate can effectively mitigate this issue and enhance chlorite recovery rate. Surface tension, solution viscosity, and foam properties tests revealed that sodium alginate improves foam stability, reducing foam generation time and increasing liquid volume in the foam layer. Theoretical analysis of Plateau's foam structure balance law supports these findings.
MINERALS ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Ayuta Kishimoto, Ryosuke Ohtsubo, Yuta Okada, Kenta Sugiyama, Hisataka Goda, Toshikazu Yoshikawa, Masahiro Kohno, Koji Fukui
Summary: With the spread of coronavirus infections, the demand for disinfectants like sodium chlorite solution has increased globally. However, the composition of sodium chlorite solutions and their bactericidal power are not well understood. This study aims to elucidate the composition of sodium chlorite solutions using spectroscopy and ion chromatography (IC) and found that commercially available sodium chlorite solution is 80% pure, potentially containing sodium hypochlorite solution. The research also discovered that the acidic sodium chlorite solution contains oxidizing species with an absorption peak at 365 nm.
Article
Chemistry, Physical
Yao Guo, Zhikai Fu, Sili Ren
Summary: This study investigated the impact of fine chlorite on the flotation behavior of smithsonite and the dispersing effect of sodium lignosulfonate (SLS). The results showed that the addition of SLS significantly improved the flotation efficiency of smithsonite by preventing the adsorption of chlorite and maintaining its hydrophilic surface.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Applied
Maria Laura Alfieri, Lucia Panzella, Orlando Crescenzi, Marco d'Ischia, Alessandra Napolitano
Summary: The study reports the synthesis of a symmetric homolog of the bibenzothiazine system, showing excellent photochromic, solvatochromic, and acidichromic properties. The cyanine structure exhibited intense absorption peaks at different wavelengths under varying pH conditions, along with a marked color change from red to deep blue in response to acid exposure. The acidichromic behavior of the cyanine was reversible and showed potential applications as pH sensors for monitoring food freshness.
Article
Agriculture, Multidisciplinary
Lucia Panzella, Alessandra Napolitano
Summary: This article provides an overview of the structural features, accessible sources, methods of analysis, and functional properties of condensed tannins (CT), highlighting the opportunities offered by these natural phenolic compounds for the rational design of multifunctional and sustainable food packaging materials.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Hiba N. Rajha, Armelle Paule, Gerard Aragones, Mariana Barbosa, Carla Caddeo, Esperance Debs, Rada Dinkova, Gunter P. Eckert, Ariel Fontana, Prisca Gebrayel, Richard G. Maroun, Alessandra Napolitano, Lucia Panzella, Giulio Maria Pasinetti, Jan F. Stevens, Andreas Schieber, Marvin Edeas
Summary: Polyphenols have attracted researchers from various disciplines due to their diverse biological activities. The latest scientific research has focused on polyphenol interactions with the microbiome and mitochondria, as well as their potential applications in cosmetics, dietary supplements, and functional foods. Polyphenols may play a key role in disease prevention and have promising prospects in future food and nutrition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Laura Alfieri, Lucia Panzella, Riccardo Amorati, Alice Cariola, Luca Valgimigli, Alessandra Napolitano
Summary: The activity of natural phenols is primarily associated with their antioxidant potential and is expressed in various biological effects. Molecular scaffold manipulation of these compounds is a sought-after approach to enhance or modulate their properties. The insertion of S/Se/Te containing substituents on phenols can increase/decrease their H-donor/acceptor ability through electronic and stereo-electronic effects. Some phenols with chalcogen substitutions exhibit better antioxidant activity than their natural counterparts.
Article
Chemistry, Applied
Lucia Panzella, Kenneth Benning, Darren N. Nesbeth, Brunella Setaro, Gerardino D'Errico, Alessandra Napolitano, Marco D'Ischia
Summary: This study purified the pigment of black sturgeon caviar and identified it as a typical black pigment through chemical degradation and electron paramagnetic resonance (EPR) evidence. Analysis of oxidative degradation mixtures revealed the formation of a specific marker of eumelanin pigments, providing a novel molecular basis for the valorization of black caviar and production wastes in food chemistry and diet.
Article
Chemistry, Organic
Maria L. Alfieri, Alice Cariola, Lucia Panzella, Alessandra Napolitano, Marco d'Ischia, Luca Valgimigli, Orlando Crescenzi
Summary: This study provides evidence for the addition mechanism of thiol compounds to quinones and discovers an anomalous 1,6-type regiochemistry compared to the usual 1,4-nucleophilic addition. These findings would prompt a revision of the commonly accepted mechanisms for thiol-quinone conjugation and stimulate further research in this field.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Vincent Ball, Maria Laura Alfieri, Kevin Ziegler, Youri Arntz, Marco d'Ischia
Summary: The deposition efficiency and electrochemical properties of coatings obtained from different benzenediols were compared. Resorcinol showed higher deposition efficiency compared to catechol, while hydroquinone did not form detectable coating. Catechol and hydroquinone exhibited reversible electrochemical properties, while resorcinol displayed an irreversible process. The results provide insights for future studies on coating design and tailoring.
SURFACES AND INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Rita Argenziano, Federica Moccia, Rodolfo Esposito, Gerardino D'Errico, Lucia Panzella, Alessandra Napolitano
Summary: This study reports an efficient strategy for the recovery of antioxidant lignins from edible nut shells using ball milling and deep eutectic solvent treatment. The recovered lignins exhibited promising antioxidant properties, opening new perspectives for their application in various fields.
Article
Biochemistry & Molecular Biology
Ugo D'Amora, Alessandra Soriente, Alfredo Ronca, Stefania Scialla, Martina Perrella, Paola Manini, Jun Wei Phua, Christoph Ottenheim, Rocco Di Girolamo, Alessandro Pezzella, Maria Grazia Raucci, Luigi Ambrosio
Summary: An optimized extraction protocol for eumelanins from black soldier flies was used to study natural eumelanin pigments and develop sustainable scaffolds. Based on methacrylated hyaluronic acid and BSF-Eumel, 3D printed scaffolds exhibited favorable physico-chemical, mechanical, and biological properties to support the growth and differentiation of human mesenchymal stem cells.
Article
Biochemistry & Molecular Biology
Sara Viggiano, Lucia Panzella, Maria Reichenbach, Joachim Hans, Alessandra Napolitano
Summary: Immediate pigment darkening, the rapid onset of melanin pigmentation resulting from oxidation, can lead to irregular pigmentation and dark spots. Phenolic cosmetic ingredients (CIs) such as paradol-6 and phenylethyl resorcinol can decrease the oxidation and melanin formation of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA). CIs also show photoprotective effects in model systems, reducing peroxidation and generation of reactive oxygen species. These findings have potential implications for the development of skincare formulations to improve skin spots and counteract aging processes associated with sun exposure.
Article
Biochemistry & Molecular Biology
Rita Argenziano, Maria Laura Alfieri, Noemi Gallucci, Gerardino D'Errico, Lucia Panzella, Alessandra Napolitano
Summary: The search for new synthetic melanin-related pigments with antioxidant and photoprotective properties is important for dermo-cosmetic purposes. In this study, a melanin derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) was synthesized and found to have similar structural properties to DHICA melanin. The synthesized pigment demonstrated stronger UV-visible absorption and improved solubility compared to DHICA melanin. Furthermore, the pigment exhibited marked antioxidant properties and enhanced inhibitory action against lipid peroxidation. These findings suggest that the melanin derived from DHICA has potential as a functional ingredient in dermo-cosmetic formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anna Mariano, Ines Fasolino, Nikita Bhupesh Dinger, Claudia Latte Bovio, Irene Bonadies, Alessandro Pezzella, Luigi Ambrosio, Maria Grazia Raucci, Francesca Santoro
Summary: During neural system development, neurons respond to cues found in the brain's environment, and these cues have been used in neural tissue engineering to create scaffolds that can guide neuronal behavior. Anisotropic aligned fibers, mimicking natural fiber structures, have proven effective in promoting cell alignment and neuronal differentiation. Melanins, including eumelanin, possess beneficial properties and have been used as coatings. Aligned poly(lactic acid) fibers coated with eumelanin promote cell alignment, morphology, and maturation of neuroblastoma cells.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Carmela Spagnuolo, Federica Moccia, Idolo Tedesco, Eva Adabbo, Lucia Panzella, Gian Luigi Russo, Alessandra Napolitano
Summary: The extract obtained from the waste of fermented strawberry distillate production exhibited high antioxidant and antiproliferative properties, mainly attributed to the presence of ellagic acid and p-coumaric acid. It showed strong antiproliferative effects on human cancer cell lines, especially on HL-60 cells, through rapid apoptosis induction. The extract also exhibited antioxidant activity and modulation of cellular oxidative stress and signaling pathways.
Article
Nanoscience & Nanotechnology
Brigida Silvestri, Paolo Armanetti, Giulio Pota, Giuseppe Vitiello, Alessandro Pezzella, Luca Menichetti, Vincenzo Giannini, Giuseppina Luciani
Summary: Photoacoustics is an increasingly recognized biomolecular imaging technique due to its non-invasiveness, deep penetration, high spatial resolution, and excellent endogenous contrast. Recent research has shown that a self-structured biocompatible nanoprobe, consisting of ternary hybrid nanoparticles with a silver core and a melanin component embedded into a silica matrix, exhibits excellent photoacoustic response. The interaction between eumelanin and silver is found to play an important role in the in situ-generated metal-organic interface. By systematically varying the metal/melanin component, the stability and intensity of the photoacoustic response can be tuned for various biomedical and theranostic applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Fabio Mocerino, Alessandro Pezzella, Ugo Caruso
Summary: A novel dihydroxyindole derivative with metal chelation properties was achieved by introducing the 2-amino-6-methylbenzothiazole chromophore at the carboxyl group of the melanin precursor. The interaction of the new amide derivative with metal ions was systematically investigated for potential use in charge storage systems, and the stoichiometry of the zinc-amide complex was determined in comparison with the parent 2-carboxy-5,6-dihydroxyindole.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
